小柴胡汤对感染性乙肝病毒肝炎患者肝功能与HBV-DNA拷贝数的影响  

Effect of Xiao Chaihu decoction on liver function and HBV-DNA copies of patients with hepatitis B virus infection

作　　者：夏莉[1] 陈新瑜[1] 李小清[1] 杨浦娟 刘华宝[1] XIA Li, CHEN Xin-yu, LI Xiao-qing, YANG Pu-juan, LIU Hua-bao(Chongqing Traditional Chinese Medicine Hospital ,Chongqing 40021, Chin)

机构地区：[1]重庆市中医院肝病科,重庆400021

出　　处：《中华医院感染学杂志》2018年第6期827-830,共4页Chinese Journal of Nosocomiology

基　　金：重庆市科技计划基金资助项目(重科技2016016)

摘　　要：目的探讨小柴胡汤对感染性乙肝病毒肝炎患者肝功能、HBV-DNA拷贝数的影响。方法选取2012年4月-2015年11月医院肝病科住院及门诊治疗的感染性乙肝病毒肝炎患者96例,分为对照组与试验组,各48例,对照组采用常规抗病毒、保肝降酶治疗;试验组在上述治疗上采用小柴胡汤加减治疗,两组持续治疗4周为一疗程,治疗前后测定患者肝功能、HBV-DNA拷贝数、肝纤维化及T淋巴细胞亚群等指标,同时对比临床疗效及不良反应状况。结果与治疗前比,两组治疗后血清AST、ALT、TBiL及HBV-DNA拷贝数降低,治疗后血清HA、ⅣC、PCⅢ及LN降低,治疗后血清CD_4^+、CD_4^+/CD_8^+升高,CD_8^+降低(P<0.05);与对照组比,试验组治疗后血清AST、ALT、TBiL及HBV-DNA拷贝数较低,治疗后血清HA、ⅣC、PCⅢ及LN较低,治疗后血清CD_4^+、CD_4^+/CD_8^+较高,CD_8^+较低(P<0.05);对照组应答率77.08%低于试验组应答率91.67%(P<0.05)。结论小柴胡汤加减有助于提高感染性乙肝病毒肝炎患者的治疗效果,显著改善肝功能,降低肝纤维化及HBV-DNA拷贝数,且安全性较为理想,可作为一种有效的治疗方案。OBJECTIVE To explore the effect of Xiao Chaihu decoction on liver function and HBV-DNA copies of patients with hepatitis B virus（HBV）infection.METHODS A total of 96 patients with HBV infection who were hospitalized in hepatopathy department and treated in outpatient department from Apr 2012 to Nov 2015 were enrolled in the study and divided into the control group and the experimental group,with 48 cases in each group.The control group was treated with conventional antiviral therapy,liver protection and reduction of enzymes,while the experimental group was given additional Xiao Chaihu decoction on basis of the above treatment,both groups were treated for 4 weeks as a course.The liver function,HBV-DNA copies,hepatic fibrosis indexes and T lymphocytes subsets were determined before and after the treatment,and the clinical curative effect and incidence of adverse reactions were observed and compared between the two groups of patients.RESULTS The levels of serum AST,ALT,TBiL and HBV-DNA copies of the two groups of patients were lower after the treatment than before the treatment,the levels of serum HA,ⅣC,PCⅢ and LN of the two groups of patients were lower after the treatment than before the treatment,the levels of serum CD_4~＋and CD_4~＋/CD_8~＋were higher after the treatment than before the treatment,and the CD_8~＋level was lower after the treatment than before the treatment（P0.05）.The levels of serum AST,ALT,TBiL and HBV-DNA of the experimental group were lower than those of the control group after the treatment;the levels of serum HA,ⅣC,PCⅢand LN of the experimental group were lower than those of the control group after the treatment,the levels of serum CD_4~＋and CD_4~＋/CD_8~＋of the experimental group were higher than those of the control group after the treatment,and the CD_8~＋level of the experimental group was lower than that of the control group（P0.05）.The response rate of the control group was 77.08%,lower than 91.67% of the experimental group（P0.05）.CONCLUSIONXiao Chaihu

关 键 词：小柴胡汤 感染性乙肝病毒肝炎 肝功能 肝纤维化 HBV-DNA拷贝数 

分 类 号：R512.62[医药卫生—内科学]