肠道外感染嗜水气单胞菌的临床相关因素及治疗对策分析  

Clinical related factors for extraintestinal infections with Aeromonas hydrophila and treatment countermeasures

作　　者：卢兰芬[1] 冯雪琴[1] 王娟[1] 罗锡华[1] 严海忠[1] 李洋 慕月晶 兰海丽[1] LU Lan-fen, FENG Xue-qin, WANG Juan, LUO Xi-hua, YAN Hai-zhong, LI Yang, MU Yue-jing, LAN Hai-li(Zhongshan People＇s Hospital, Zhongshan, Guangdong 528400, Chin)

机构地区：[1]广东中山市人民医院检验科,广东中山528400

出　　处：《中华医院感染学杂志》2018年第6期866-868,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析肠道外嗜水气单胞菌的感染情况、相关因素及其耐药性,为临床防治嗜水气单胞菌感染提供依据。方法回顾性分析2009年1月-2016年12月112例患者肠道外分离的嗜水气单胞菌112株,分析标本来源、来源季节分布及耐药性。结果嗜水气单胞菌肠道外感染好发于秋季,可在各种无菌部位引起感染,主要以伤口感染和血液感染为主,分别占40.18%及31.25%;临床患者主要伴有外科手术史、留置引流管等特点;肠道外嗜水气单胞菌对四代头孢菌素、碳青霉烯类、氨基糖苷类、喹诺酮类等药物敏感性均较好,但已有多药耐药株出现,且耐碳青霉烯菌株检出呈增高趋势。结论肠道外嗜水气单胞菌感染以中老年男性和秋季多见,其耐药性不容乐观,已出现耐碳青霉烯菌株,应引起临床高度重视。OBJECTIVE To investigate the prevalence of extraintestinal infection with Aeromonas hydrophila,related factors and drug resistance so as to provide guidance for clinical prevention and treatment of the A.hydrophilainfection.METHODS Totally 112 strains of A.hydrophila were isolated from extraintestinal specimens of 112 patients who were treated in the hospital from Jan 2009 to Dec 2016.The specimens sources,seasonal distribution and drug resistance were observed.RESULTS The extraintestinal A.hydrophila infection was highly prevalent in autumn and led to infection of sterile sites.The patients with wound infection accounted for 40.18%,the patients with blood infection 31.25%.The history of surgery and drainage tube indwelling were the major clinical characteristics of the patients.The extraintestinal A.hydrophila strains were highly susceptible to fourth generation cephalosporins,carbapenems,aminoglycosides and quinolones,however,the multidrug-resistant strains have emerged,the isolation rate of carbapenem-resistant strains showed an upward trend.CONCLUSIONThe extraintestinal A.hydrophilainfection is highly prevalent among elderly men and is most common in autumn,and it is necessary for the hospital to pay great attention to the drug resistance and the carbapenem-resistant strains.

关 键 词：肠道外 嗜水气单胞菌 易感因素 耐药性 

分 类 号：R378[医药卫生—病原生物学]