血清β-人绒毛膜促性腺激素与C-反应蛋白对胎膜早破妊娠患者宫内感染的预测效果  

Predictive rffect of serum β-hCG and CRP on intrauterine infection in pregnant women with premature rupture of membranes

作　　者：张岩[1] 杨飚[1] 范娟 徐文萍[1] 张安乐[1] 常琦 吴大保 ZHANG Yan , YANG Biao, FAN Juan, XU Wen-ping, ZHANG An-le, CHANG Qi, WU Da-bao(Matanshan Central Hospital, Matanshan , Anhui 243000, Chin)

机构地区：[1]马鞍山市中心医院妇产科,安徽马鞍山243000 [2]安徽省省立医院妇产科,安徽合肥230000

出　　处：《中华医院感染学杂志》2018年第6期911-914,共4页Chinese Journal of Nosocomiology

基　　金：安徽省科技攻关基金资助项目(150104114)

摘　　要：目的探讨血清β-人绒毛膜促性腺激素(β-hCG)、C-反应蛋白(CRP)对胎膜早破妊娠患者宫内感染的预测结果。方法选取于2014年10月-2016年12月期间医院收治的108例胎膜早破患者为研究对象,根据是否合并宫内感染,分为感染组46例和非感染组62例。产前抽取静脉血检测血清β-hCG和CRP水平,产后留取胎盘和胎膜组织,进行病理切片检查。结果感染组患者血清β-hCG为(5.56±1.63)ng/ml和CRP水平为(26.25±12.58)mg/L,均高于非感染组(P<0.05);随着感染程度的加重,不同宫内感染程度患者血清β-hCG和CRP水平比较差异有统计学意义(P<0.05);当血清β-hCG≥2.26ng/ml和CRP≥12.85 mg/L对宫内感染的诊断价值AUC最大;β-hCG联合CRP用于宫内感染的诊断时,敏感性、特异性、阳性预测值和阴性预测值均高于单一指标(P<0.05)。结论联合检测血清β-hCG和CRP对胎膜早破孕妇宫内感染的早期诊断具有较高的价值,且与患者预后密切相关。OBJECTIVE To investigate the predictive effect of serumβ-human chorionic gonadotropin（β-hCG）and C-reactive protein（CRP）on intrauterine infection in pregnant women with premature rupture of membranes.METHODS From Oct.2014 to Dec.2016,108 patients with premature rupture of membranes were enrolled in this study.According to whether the combined intrauterine infection,patients were divided into infection group（n=46）and non-infection group（n=62）.The prenatal levels of serumβ-hCG and CRP were measured,and placentas were collected for postnatal examination.RESULTS The levels of serumβ-hCG and CRP in infection group were（5.56±1.63）ng/ml and（26.25±12.58）mg/L,which were significantly higher than those in non-infection group（P0.05）.Serumβ-hCG and CRP levels were gradually increased with the increase of infection degree,and the levels of serumβ-hCG and CRP in patients with different intrauterine infection were significant（P0.05）.When the serumβ-hCG ≥ 2.26 ng/ml and CRP ≥ 12.85 mg/L,the AUC on the diagnosis of intrauterine infection was the maximum.The sensitivity,specificity,positive predictive value and negative predictive value ofβ-hCG combined with CRP for the diagnosis of intrauterine infection were significantly higher than those of the single index（P0.05）.CONCLUSIONCombined detection of serumβ-hCG and CRP is of great value in the early diagnosis of intrauterine infection in pregnant women with premature rupture of membranes and is closely related to the prognosis of patients.

关 键 词：胎膜早破 宫内感染 Β-人绒毛膜促性腺激素 C-反应蛋白 

分 类 号：R714.433[医药卫生—妇产科学]