妇炎平联合克霉唑治疗阴道炎症感染妇女的疗效研究  

Effect of Fuyanping capsules combined with clotrimazole on treatment of women with vaginitis

作　　者：崔静[1] 靳瑾[2] 林艳 符初料 文琼珺 CUI Jing , JIN Jin, LIN Yan, FU Chu-liao, WEN Qiong-jun(Dongfang People＇s Hospital, Dongfang, Hainan 572600, Chin)

机构地区：[1]东方市人民医院妇产科,海南东方572600 [2]南方医科大学南方医院妇产科,广东广州510515

出　　处：《中华医院感染学杂志》2018年第6期918-921,共4页Chinese Journal of Nosocomiology

摘　　要：目的观察妇炎平胶囊联合克霉唑阴道片治疗阴道炎症感染妇女的治疗效果。方法选取2015年1月-2016年12月医院接受治疗的182例阴道炎症感染患者为研究对象,按照入院顺序随机分为对照组和试验组,各91例,对照组给予克霉唑阴道片进行治疗,试验组在对照组的基础上,联合妇炎平胶囊进行治疗,观察两组患者治疗后的临床效果、临床症状消失的时间,治疗前后临床症状的变化情况及阴道灌洗液炎性因子和血清氧化应激产物的变化情况。结果试验组治疗总有效率为94.50%高于对照组的81.32%(χ2=7.445,P=0.009);治疗后,两组患者的外阴、阴道的红肿、瘙痒,寒战高热,排尿困难,痛经,情绪烦躁以及情感低落等临床症状均较治疗前改善,且试验组改善更明显(P<0.05);试验组治疗后白带、外阴瘙痒、外阴阴道疼痛及黏膜充血等临床症状消失的时间均短于对照组(P<0.05);与治疗前相比,两组患者的IL-2、IL-6、IL-8及MDA水平在治疗后均降低,SOD和NO水平增加(P<0.05);且试验组这些指标较对照组改善更为明显(P<0.05)。结论妇炎平胶囊联合克霉唑阴道片治疗阴道炎症感染具有良好的临床效果,能够改善患者的临床症状,缩短临床症状消失的时间,降低炎性因子以及氧化应激产物的水平,可在临床上推荐使用。OBJECTIVE To observe the effect of Fuyanping capsules combined with clotrimazole vaginal tablets on treatment of women with vaginitis.METHODS A total of 182 patients with vaginitis who were treated in hospitals from Jan 2015 to Dec 2016 were recruited as the study objects and randomly divided into the control group and the experimental group according to the order of admission to hospital,with 91 cases in each group.The control group was treated with clotrimazole vaginal tablets,while the experimental group was treated with clotrimazole vaginal tablets combined with Fuyanping capsules.The clinical effects and time of disappearance of clinical symptoms were observed,and the changes of clinical symptoms,inflammatory factors in vaginal lavage fluid and serum oxidative stress products were analyzed before and after the treatment.RESULTS The total effective rate of treatment of the experimental group was 94.50%,higher than 81.32% of the control group（χ2=7.445,P=0.009）.The clinical symptoms of the two groups of patients such as vulva,vaginal swelling,pruritus,fever and chills,dysuresia,dysmenorrhea,emotional irritability and emotional depression were improved more significantly after the treatment than before the treatment,which were improved more significantly in the experimental group than in the control group（P0.05）.The time of disappearance of clinical symptoms such as leucorrhea,vulva pruritus,vulvovaginal pain and mucosal hyperemia was significantly shorter in the experimental group than in the control group（P0.05）.The levels of IL-2,IL-6,IL-8 and MDA of the two groups of patients were significantly lower after the treatment than before the treatment,while the levels of SOD and NO were significantly elevated（P0.05）,the above indexes were improved more significantly in the experimental group than in the control group（P 0.05）.CONCLUSIONFuyanping capsules combined with clotrimazole vaginal tablets can achieve favorable clinical effect on treatment of vaginitis,improve the clinical symptoms of th

关 键 词：妇炎平胶囊 克霉唑阴道片 阴道炎症感染 

分 类 号：R711.31[医药卫生—妇产科学]