丙种球蛋白对重症手足口病患儿细胞因子、hs-cTn、NSE和S-100β蛋白的影响  

Effect of gamma globulin on cytokines, hs-cTn, NSE and S-100 beta protein in the children with severe hand-foot-mouth disease

作　　者：幸黔鲁[1] 张娇月 白国辉[2] 杨雯 XIN Qian-lu1, ZHANG Jiao-Yue1, BAI Guo-hui2, YANG Wen3(1. Department of Pediatric, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China; 2. Central laboratory of Zunyi Medical University, Zunyi 563003, China; 3. the Second People＇s Hospital of Zunyi, Zunyi 563000, Chin)

机构地区：[1]贵州省遵义医学院附属医院儿科,贵州遵义563003 [2]贵州省遵义医学院中心实验室,贵州遵义563003 [3]贵州省遵义市第二人民医院,贵州遵义563000

出　　处：《广东医科大学学报》2017年第5期522-525,共4页Journal of Guangdong Medical University

摘　　要：目的探讨丙种球蛋白对重症手足口病(HFMD)患儿炎症细胞因子、hs-cTn、NSE和S-100β蛋白的影响。方法将88例重症HFMD患儿随机分为观察组(44例)和对照组(44例)。对照组给予常规方案治疗,观察组在常规治疗的基础上给予丙种球蛋白。评估两组的疗效,检测两组患儿治疗前后的白介素-6(IL-6)、IL-8、IL-10、干扰素-γ(INF-γ)、肿瘤坏死因子-α(TNF-α)、高敏心肌肌钙蛋白(hs-cTn)、神经元特异性烯醇化酶(NSE)和S-100β蛋白的水平。结果观察组的总有效率明显高于对照组(P<0.05)。两组治疗后的IL-6、IL-8、INF-γ、TNF-α、hs-cTn、NSE和S-100β蛋白水平均明显低于治疗前,IL-10水平明显高于治疗前,且以观察组更加明显(P<0.05)。结论丙种球蛋白可明显提高重症HFMD的疗效和调节免疫紊乱,并可明显降低hs-cTn、NSE和S-100β蛋白水平。Objective To investigate the effect of gamma globulin on inflammatory cytokine,high sensitivity cardiac troponin（hs-cTn）,neuron-specific enolase（NSE）and S-100 beta protein in the children with severe hand-foot-mouth disease（HFMD）.Methods Eighty-eight children with severe HFMD were randomly divided into Observation Group（44 cases）and Control Group（44 cases）.The Control Group was given routine treatment while the Observation Group was given gamma globulin on the basis of routine treatment.The efficacy of the two groups was evaluated.The concentrations of interleukin-6（IL-6）,IL-8,IL-10,interferon gamma（INF-γ）,tumor necrosis factor alpha（TNF-α）,hs-cTn,NSE,and S-100 beta protein of the two groups were measured before and after treatment.The data of two groups were compared by using chi square test and t test.Results The total effective rate of the Observation Group was significantly higher than that of the Control Group（P〈0.05）.The concentrations of IL-6,IL-8,INF-γ,TNF-α,hs-cTn,NSE and S-100 in the two groups were significantly lower than those before treatment,but Observation Group showed a more significant decrease（P〈0.05）.The concentration of IL-10in the two groups was significantly higher than that before treatment,but Observation Group showed a more significant increase（P〈0.05）.Conclusion Gamma globulin can significantly improve the curative effect of severe HFMD and regulate the immune disorder,and significantly reduce the concentration of hs-cTn,NSE and S-100 beta protein.

关 键 词：手足口病 丙种球蛋 疗效 细胞因子 高敏心肌肌钙蛋白 神经元特异性烯醇化酶 S-100Β蛋白 

分 类 号：R725.1[医药卫生—儿科]