从分子结构出发探索TPP分子用于生物成像与光学治疗的潜能  

The Molecular Structure of TPP and Its Potential for Bio-Imaging and Photo-Therapy

作　　者：张佳丽 孟晓青[1,2] 孙枝红 龚萍 ZHANG Jiali1,2 MENG Xiaoqing1,2 SUN Zhihong1 GONG Ping1 1(Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China ） 2（ University of Chinese Academy of Sciences, Beijing 100049, China)

机构地区：[1]中国科学院深圳先进技术研究院,深圳518055 [2]中国科学院大学,北京100049

出　　处：《集成技术》2018年第2期78-88,共11页Journal of Integration Technology

基　　金：科技部港澳台专项(2015DFH50230);国家自然科学基金项目(21375141;81671758);深圳市专项资金项目(JSGG20160331185422390;JCYJ20150403091443298;JCYJ20150521094519473;JCYJ20160429191503002)

摘　　要：5-(4-羧基苯基)-10,15,20-三苯基卟啉(TPP)是具有高度对称性和大π共轭结构的分子,属于卟啉衍生物。卟啉是血红素、叶绿素等多种生物成分的关键前体,结构上的特殊性使其呈现出特征的光学特性。该文通过检测不同溶液条件下TPP的电子吸收和分子发射光谱的变化,探讨溶液极性、pH等对其光学性能的影响,测量分子的质子化能力,并与理论计算值互相推演,探究可能出现这些现象的分子结构变化。最后,根据体外溶液和肿瘤细胞中光动力效果预测其在肿瘤的光动力治疗方面的潜能。5-（4-Carboxyphenyl）-10,15,20-triphenylporphyrin （TPP） is a porphyrin derivation with high symmetry and conjugated n bond. Porphyrins are critical precursor of many bio-compounds, such as heme and chloroplast. And its unique structure contributes to a special spectroscopy. In this article, the effect of polarity and pH of solution on the optical property of TPP was analyzed by detecting the absorption and emission spectra in different solvent. Then, we discussed how the molecular structure changed before and after protonation by theoretically circulating several basic parameter of different conformations. Finally, we predicted its prospects for photodynamic therapy according to the photodynamic reaction efficiency shown in vitro.

关 键 词：5-(4-羧基苯基)-10 15 20-三苯基卟啉 分子结构 光谱 质子化常数 光动力反应 

分 类 号：O621.4[理学—有机化学]