水飞蓟宾导致慢性肝炎患者缺铁性贫血的研究  

Study on Iron Deficiency Anemia in Patients with Chronic Hepatitis Caused by Silibinin

作　　者：朱凌云[1] 童宁[1] 俞斐[1] 齐雪静 Zhu Lingyun, Tong Ning, Yu Fei, Qi Xuejing(The Second Hospital of Nanjing, Nanjing 210003, Chin)

机构地区：[1]南京市第二医院,南京210003

出　　处：《中国药事》2018年第3期384-387,共4页Chinese Pharmaceutical Affairs

基　　金：南京药学会-常州四药医院药学科研基金资助项目(编号2014YX010)

摘　　要：目的:研究水飞蓟宾对慢性肝炎患者缺铁性贫血的影响。方法:选取120例慢性肝炎患者分为两组(每组60例),两组患者在性别、年龄、临床类型及肝功能等实验室检查指标上均无显著性差异。对照组服用多烯磷脂酰胆碱(易善复,赛诺菲安万特制药有限公司),剂量为70~140 mg,口服,每日3次,12周为一个疗程;试验组服用水飞蓟宾(水林佳,天津天士力制药有限公司),剂量为70~140 mg,口服,每日3次,12周为一个疗程。两组于治疗前、治疗2周、治疗结束后4周测定血红蛋白、血清铁蛋白、血清铁。结果:对照组60例中,服药前后,血红蛋白、血清铁蛋白、血清铁均无显著变化;试验组60例,给药后血红蛋白、血清铁蛋白、血清铁的差异有显著性意义(P<0.05)。结论:水飞蓟宾会导致慢性肝炎患者缺铁性贫血的发生。Objective： To study the effect of Silibinin on iron deficiency anemia in patients with chronic hepatitis. Methods： 120 patients with chronic hepatitis were selected into two groups（60 patients per group）. There was no significant difference between the two groups in the laboratory test indicators, such as gender, age, clinical types and liver function. Control group was orally administrated polyene phosphatidylcholine（Essentiale, Sanofi-Aventis Pharmaceutical Co., Ltd） at the dose of 70-140 mg, tid for 12 weeks. Experimental group was orally administrated Silibinin（Silibinin capsules, Tianjin Tasly Pharmaceutical Co., Ltd） at the dose of 70-140 mg, tid for 12 weeks. Hemoglobin, serum ferritin and asrum iron were measured before the treatment, two weeks after treatment and four weeks after the end of the treatment in two groups. Results： There was no significant difference of the hemoglobin, serum ferritin and asrum iron of the 60 patients in the control group before and after the treatment. On the contrary, there was significant differences of the hemoglobin, serum ferritin and serum iron of the 60 patients in the experimental group before and after the treatment（P0.05）. Conclusion： Silibinin could cause iron deficiency anemia in patients with chronic hepatitis.

关 键 词：水飞蓟宾 多烯磷脂酰胆碱 慢性肝炎 缺铁性贫血 

分 类 号：R951[医药卫生—药学]