Oleylamine-catalyzed Tandem Knoevenagel/Michael Addition of 1,3-Cyclohexanediones with Aromatic Aldehydes  

作　　者：HE Xinwei WU Yuhao FAN Chenli LU Peng ZUO Youpeng SHANG Yongjia 

机构地区：[1]Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-based Materials(State Key Laboratory Cultivation Base), College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, R R. China [2]Department of Material Engineering, Wuhu Institute of Technology, Wuhu 241003, P. R. China

出　　处：《Chemical Research in Chinese Universities》2018年第2期186-190,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（Nos.21772001, 21372008）, the Natural Science Foundation of Education Administration of Anhui Province, China（No.KJ2016A267）, the Special and Excellent Research Fund of Anhui Normal Universit and the Doctoral Scientific Research Foundation of Anhui Normal University, China（No.2016XJJ110）.

摘　　要：A convenient and efficient method was developed for the synthesis of 2,2＇-（arylmethylene）bis（3-hydrox- ycyclohex-2-enone） derivatives via the oleylamine-catalyzed tandem Knoevenagel/Michael addition reactions of aromatic aldehydes and cyclohexane-1,3-diones. This transformation proceeded without any metal catalyst in non-toxic solvent at room temperature with high isolated yields. A plausible mechanism for this process was pro- posed.A convenient and efficient method was developed for the synthesis of 2,2＇-（arylmethylene）bis（3-hydrox- ycyclohex-2-enone） derivatives via the oleylamine-catalyzed tandem Knoevenagel/Michael addition reactions of aromatic aldehydes and cyclohexane-1,3-diones. This transformation proceeded without any metal catalyst in non-toxic solvent at room temperature with high isolated yields. A plausible mechanism for this process was pro- posed.

关 键 词：2 2＇-（Arylmethylene）bis（3-hydroxycyclohex-2-enone） Knoevenagel condensation Michael addition OLEYLAMINE Tandem reaction 

分 类 号：O622.4[理学—有机化学] TQ426.8[理学—化学]