An Efficient Method for Sulfonylation of Amines, Alcohols and Phenols with N-Fluorobenzenesulfonimide Under Mild Conditions  

作　　者：JING Li YU Xinling GUAN Mei WU Xiaohua WANG Qiantao WU Yong 

机构地区：[1]Key Laboratory of Drug-targeting of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China [2]West China Hospital, Sichuan University, Chengdu 610041, P. R. China

出　　处：《Chemical Research in Chinese Universities》2018年第2期191-196,共6页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（Nos. 81373259, 81573286）.

摘　　要：A new and convenient procedure was developed for the preparation of sulfonamides and sulfonic esters using N-fluorobenzenesulfonimide（NFSI） as a novel phenylsulfonyl group transfer reagent. In this protocol, a broad range of functional groups were tolerated to give the corresponding sulfonamides or sulfonic esters in moderate to excellent yields. The synthetic strategy for sulfonamides formation proceeded efficiently even under base-, metal- and additive-free conditions with the advantages of operational simplicity, mild reaction conditions as well as short reaction time.A new and convenient procedure was developed for the preparation of sulfonamides and sulfonic esters using N-fluorobenzenesulfonimide（NFSI） as a novel phenylsulfonyl group transfer reagent. In this protocol, a broad range of functional groups were tolerated to give the corresponding sulfonamides or sulfonic esters in moderate to excellent yields. The synthetic strategy for sulfonamides formation proceeded efficiently even under base-, metal- and additive-free conditions with the advantages of operational simplicity, mild reaction conditions as well as short reaction time.

关 键 词：N-Fluorobenzenesulfonimide SULFONYLATION SULFONAMIDE Sulfonic ester 

分 类 号：O623.624[理学—有机化学] TQ522.1[理学—化学]