高龄Ⅲ型前列腺炎患者血清和前列腺液中神经生长因子、炎性因子的表达水平及临床意义  被引量:15

Expressions and Clinical Significances of Nerve Growth Factor and Inflammatory Factors in Serum and Expressed Prostatic Secretions in the Elderly Patients with Prostatitis

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作  者:朱云海 许云飞[1] 陈耀武[2] 孟军[2] 舒畅[2] ZHU Yun-hai 1.2, XU Yan-fei 1, CHEN Yao-wa, MENG Jun2, SHU Chang2(1 Department of Urology, the l Oth People's Hospital, Tongji University, Shanghai, 200072, China; 2 Department of Urology, Baoshan Branch, Shanghai First People's Hospital, Shanghai, 200940, Chin)

机构地区:[1]同济大学附属第十人民医院泌尿外科,上海200072 [2]上海市第一人民医院宝山分院泌尿外科,上海200940

出  处:《现代生物医学进展》2018年第2期272-275,共4页Progress in Modern Biomedicine

摘  要:目的:探讨高龄Ⅲ型慢性前列腺炎(CP)患者血清和前列腺液(EPS)中神经生长因子(NGF)、炎性因子的表达水平及其临床意义。方法:收集2015年5月~2016年12月我院收治的150例高龄Ⅲ型CP患者(CP组),其中ⅢA型81例,ⅢB型69例,另选择150例健康体检者作为对照(对照组)。采用双抗体夹心酶联免疫吸附法(ABC-ELISA)检测其血清、EPS中NGF、IL-8和TNF-α的表达水平,分析NIH-CPSI、NGF、IL-8和TNF-α之间的相关性。结果:CP组血清、EPS中TNF-α、IL-8、NGF水平均明显高于对照组(P<0.05);与IIIB型患者比较,IIIA型患者TNF-α、IL-8水平明显升高(P<0.05);EPS中TNF-α、IL-8、NGF水平均明显高于血清(P<0.05)。IIIB型患者的NIH-CPSI症状评分明显低于IIIA型(P<0.05)。CP患者EPS中NGF和TNF-α、IL-8均呈显著正相关(P<0.05);血清中NGF和TNF-α、IL-8亦呈显著正相关(P<0.05)。III型CP患者血清、EPS中,TNF-α、IL-8、NGF与NIH-CPSI呈显著正相关(P<0.05)。结论:高龄III型CP患者血清、EPS中TNF-α、IL-8、NGF表达水平明显升高,且与NIH-CPSI明显相关,联合检测有助于评估III型CP患者的病情严重程度。Objective: To explore the expressions and clinical significances of nerve growth factor(NGF) and inflammatory factors in serum and expressed prostatic secretions(EPS) in the elderly patients with chronic prostatitis(CP). Methods: Patients with Type Ⅲ CP(CP group) who were admitted from December 2013 to December 2016 and 150 cases of healthy controls were selected. CP group included 81 cases of Type Ⅲ A CP, 69 cases of Type Ⅲ B CP. The NGF, IL-8 and TNF-α levels in serum and EPS were detected by ABC-ELISA, and the correlation of NIH-CPSI, NGF, IL-8 with TNF-α were analyzed. Results: The levels of TNF-α, IL-8 and NGF in serum, EPS in CP group were significantly higher than those of the control group(P0.05). Compared with the type IIIB CP, the levels of TNF-α, IL-8 in type IIIA CP were significantly increased(P0.05). The levels of TNF-α, IL-8 and NGF in EPS were significantly higher than those in the serum(P0.05). The NIH-CPSI symptom scores of patients with type IIIB CP was significantly lower than that of patients with type IIIA CP(P0.05). The levels of TNF-α, IL-8 in serum and EPS of CP patients had significantly positive correlation with NGF(P0.05). There was positive correlation of TNF-α, IL-8, NGF with NIH-CPSI in serum and EPS of CP patients(P0.05).Conclusions: The levels of TNF-α, IL-8, NGF in serum and EPS of elderly patients with type III CP were highly expressed and closely correlated with the NIH-CPSI. Combination detection of TNF-α, IL-8, NGF could contribute to evaluate the severity of CP.

关 键 词:慢性前列腺炎 高龄 神经生长因子 炎性因子 慢性前列腺症状指数 

分 类 号:R697.33[医药卫生—泌尿科学]

 

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