糖皮质激素治疗结核性胸膜炎的应用及作用机制  

Application of glucocorticoid in the treatment of tuberculous pleurisy and analysis of its mechanism

作　　者：朱丽颖[1] ZHU Li-ying

机构地区：[1]辽宁省沈阳市皇姑区结核病防治所,辽宁沈阳110000

出　　处：《中国药物经济学》2018年第3期69-71,共3页China Journal of Pharmaceutical Economics

摘　　要：目的探讨糖皮质激素治疗结核性胸膜炎的应用及作用机制。方法选取2016年7月至2017年7月沈阳市皇姑区结核病防治所收治的结核性胸膜炎患者100例为研究对象,分为对照组和研究组,每组50例。对照组患者口服醋酸泼尼松治疗,研究组患者在此基础上注射地塞米松,比较两组患者治疗效果极其相关指标。结果研究组患者的治疗有效率为98.0%,较对照组的68.0%更高,差异有统计学意义(P<0.05)。与对照组比较,研究组患者的治疗后IL-6及IL-8水平、全身中毒缓解时间、胸腔积液吸收和住院时间、胸膜粘连增厚发生率明显较低,差异均有统计学意义(P<0.05)。结论以口服泼尼松为基础,联合注射地塞米松开展治疗,可以缓解结核性胸膜炎患者的炎性症状,加速胸水吸收率,减少胸膜粘连增厚的发生,缩短治疗时间。Objective To investigate the application and mechanism of glucocorticoid in the treatment of tuberculous pleurisy. Methods 100 cases of tuberculous pleurisy patients admitted from July 2016 to July 2017 in Huanggu District of Shenyang City were selected as study objects. All patients were divided into two groups, with 50 cases in each group. The control group was treated with oral prednisolone acetate. Based on this, dexamethasone was injected into the study group, and the related results were analyzed. Results The efficacy of study group was 98.00%, which was significantly higher than that of control group 68.00%（P〈0.05）. Compared with the control group, the incidence of IL-6 and IL-8, systemic poisoning time, pleural effusion absorption and length of hospital stay, and pleural thickening were significantly lower in the study group（P〈0.05）. The clinical effect was significantly better（P〈0.05）. Conclusion The combination of oral prednisone and dexamethasone can relieve the inflammatory symptoms, accelerate the absorption rate of pleural effusion, reduce the thickening of pleural adhesions, save the treatment Cost, shorten the treatment time, thus it is worth further promotion.

关 键 词：泼尼松片 地塞米松 结核性胸膜炎 作用机制 临床效果 

分 类 号：R521.7[医药卫生—内科学]