视网膜光凝术联合药物治疗糖尿病视网膜病变疗效及其对血管内皮生长因子、类胰岛素一号增长因子水平的影响  

Clinical effect of retinal photocoagulation combined with drug on retinopathy of diabetic retinopathy and its effect on VEGF and IGF -1 level

作　　者：李高春[1] 林咸平[1] 王乐丹 李恩辉[1] Li Gaochun,Lin Xianping,Wang Ledan,Li Enhui.(Department of Ophthalmology, Taizhou Hospital of Zhejiang Province ,Linhai ,Zhejiang 317000, Chin)

机构地区：[1]浙江省台州医院眼科,浙江省临海317000

出　　处：《中国基层医药》2018年第8期965-968,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省医药卫生科技计划项目（2011KYB136）

摘　　要：目的探讨视网膜光凝术联合复方樟柳碱治疗糖尿病视网膜病变的效果及对患者血管内皮生长因子（VEGF）、类胰岛素一号增长因子（IGF-1）的影响。方法选取糖尿病视网膜病变患者116例，采用随机数字表法分为观察组和对照组，每组58例，对照组给予视网膜光凝手速治疗，观察组联合复方樟柳碱治疗，比较两组治疗效果；并比较两组VEGF、IGF-1水平变化。结果观察组治疗总有效率为93．10％，显著高于对照组的77．59％，组间差异有统计学意义（χ^2=5．582，P〈0．05）。观察组水肿吸收时间（4．19±1．24）d，出血吸收时间（2．19±1．01）d，渗出吸收时间（9．48±2．13）d；对照组水肿吸收时间（5．83±2．85）d，出血吸收时间（3．25±1．88）d，渗出吸收时间（13．54±3．88）d，组间差异均有统计学意义（t=4．018、3．782、6．985，均P〈0．05）。观察组治疗后VEGF（85．12±4．64）ng／L，IGF-1（90．17±4．95）μg／L；对照组治疗后VEGF（100．48±9．26）ng／L,IGF-1（132．69±10．04）μg／L，组间差异均有统计学意义（t=11．294、28．928，均P〈0．05）。结论视网膜光凝术联合复方樟柳碱联合方案应用在糖尿病视网膜病变中可以提升临床疗效，促进患者视力恢复，调节血管内皮生长因子水平，值得在临床推广应用。Objective To explore the effect and application value of retinal photocoagulant combined with compound anisodine in the treatment of diabetic retinopathy, and its effect on vascular endothelial growth factor （VEGF） and insulin - like growth factor - 1 （ IGF - 1 ） level. Methods 116 patients with diabetic retinopathy were selected ,and they were randomly divided into observation group and control group according to the digital table,58 cases in each group. The control group was given retinal photoeoagnlation treatment, and the observation group was given retinal photocoagulation combined with compound anisodine treatment. The therapeutic effect was compared between the two groups. Results The total effective rate of the observation group was 93.10%, which was significantly higher than 77.59% of the control group,and the difference between the two groups was statistically significant （χ^2 = 5. 582,P 〈0.05）. The edema absorption time, bleeding absorption time, exudate absorption time of the observation group were （4.19 ± 1.24） d, （2. 19 ± 1.01 ） d, （9.48 ± 2. 13 ） d, respectively, which of the control group were （5.83 ± 2.85 ） d, （3.25 ± 1.88 ） d, （ 13.54 ± 3.88 ） d, respectively, and the differences between the two groups were statistically significant （t =4.018,3. 782,6.985 ,all P 〈0.05）. After treatment,the VEGF and IGF - 1 levels in the observation group were （85.12 ± 4.64） ng/L, （ 90. 17 ± 4.95 ）μg/L, respectively, which in the control group were （100.48 ±9.26）ng/L, （132. 69 ± 10.04 ）μg/L, respectively, the differences between the two groups were statistically signifieant （t = 11. 294,28. 928, all P 〈 0. 05）. Conclusion Retinal photoeoagttlation surgery combined with compound anisodine in the treatment of diabetic retinopathy can improve clinical curative effect, promote the patients＇visual acuity, adjust the concentration of VEGF, the effect is remarkable, it is worthy of popularizing in clinical application.

关 键 词：激光凝固术 糖尿病视网膜病变 血管内皮生长因子 类胰岛素样生长因子1 

分 类 号：R587.2[医药卫生—内分泌] R779.63[医药卫生—内科学]