石楠藤等7种活血化瘀中药对老年痴呆模型小鼠记忆力影响的比较研究  

Comparison Study on Effect of Seven Kinds of Activating Blood Circulation Chinese Herbs on Memory of Mice with Alzheimer's Disease

作　　者：陈少奇 吕敏[1] CHEN Shaoqi, LV Min(Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053)

机构地区：[1]浙江中医药大学,浙江杭州310053

出　　处：《中国中医药科技》2018年第2期202-204,共3页Chinese Journal of Traditional Medical Science and Technology

基　　金：浙江省中医药科技计划项目(2012ZB030)

摘　　要：目的:探讨石楠藤等7种活血化瘀中药的抗老年痴呆作用。方法:建立侧脑室注射Aβ_(25-35)制备小鼠痴呆(AD)模型,以Morris水迷宫逃避潜伏期和寻找平台游泳距离为观察指标,观察石楠藤等7种活血化瘀中药对AD模型小鼠学习记忆能力的影响。结果:石南藤提取物组小鼠的逃避潜伏期以及寻找平台游泳距离均出现明显地缩短(P<0.05),其他各中药提取物(郁金、鸡血藤、生蒲黄、赤芍、益母草、穿山甲)灌胃后,AD模型小鼠逃避潜伏期和寻找平台游泳距离在测试中无明显的差异。结论:石南藤提取物可以明显提高AD模型小鼠的学习记忆能力,拮抗或修复Aβ_(25-35)对小鼠学习能力的损伤。Objective： To investigate effect of 7 kinds of activating blood circulation Chinese Herbs on Alzheimer＇s disease mice model. Methods： Dementia models were established by lateral ventricle injection Aβ25-35. Morris water maze was applied to observe the escape latency and the distances looking for a platform, the effect of 7 kinds of activating blood circulation Chinese Herbs on memory improving was evaluated. Results ： After intragastric administration , Shinanteng （Piper wallichii ）extract could shortened escape latency and swim- ming distance finding platform obviously （P 〈 0. 05 ）, the escape latency and swimming distance looking for plat- form of mice in the other activating blood circulation Chinese Herbs extract （ Curcumae Radix, Caulis Spatholobi, Pollen Typhae Angustifoliae, Radix Paeoniae Rubra, Leonurus Japonicus, Sq Manthis Pentadactylis ） , were no ob- vious difference to compare with model group in the test. Conclusion： Piper wallichii can improve the ability of learning and memory in mice with Alzheimer＇ s disease ,repair the cerebral injury caused by Aβ25-35.

关 键 词：老年痴呆 石楠藤 活血化瘀 记忆 小鼠 

分 类 号：R285.5[医药卫生—中药学] R-332[医药卫生—中医学]