O-GlcNAc修饰调控软骨及成骨分化的研究进展  

Research Progress of O-GlcNAc Modification in Regulation of Cartilage and Osteogenic Differentiation

作　　者：高婧 施美霞 寸镜芬 赵舒融 黄春荣 许艳华[1] GAO Jing, SHI Mei-xia, CUN Jing-fen, ZHAO Shu-rong, HUANG Chun-rong, XU Yan-hua(Dept. of Orthodontics, Stomatological Hospital of Kunming Medical University, Kunming, Yunnan, 650000, Chin)

机构地区：[1]昆明医科大学附属口腔医院正畸科,云南昆明650000

出　　处：《现代生物医学进展》2018年第3期569-572,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81260162)

摘　　要：O-GlcNAc糖基化属于蛋白质的翻译后修饰,参与了基因转录、信号转导、细胞分化等重要的细胞生命活动。软骨细胞与成骨细胞是骨骼系统中两种重要的细胞,它们的分化对骨的形成有重要意义。近年来研究表明O-GlcNAc糖基化通过调节多个信号通路中关键分子的活性影响软骨及成骨细胞的分化。为了更好的阐明O-GlcNAc糖基化调控软骨及成骨分化的分子机制,以期为骨关节炎、骨质疏松治疗提供新的干预靶点,我们对O-GlcNAc糖基化调控软骨及成骨分化的研究现状做如下综述。The O-GlcNAcylation as the post-translational modification（PTM） of protein, involves in important life activities such as gene transcription, signal transduction, cell differentiation. Chondrocytes and osteoblasts are two important cells in the skeletal system, and their differentiation is important for bone formation. Recent studies show that the O-GlcNAcylation affects the differentiation of chondrocytes and osteoblasts by regulating the activity of key molecules in multiple signaling pathways. In order to further elucidate the molecular regulation mechanism of O-GlcNAcylation in Chondrocytes and osteoblasts differentiation, and hopefully provide new intervention targets and new therapy strategy for clinical treatment of osteoarthritis and osteoporosis in future, we mainly overview the currunt study of how the O-GlcNAcylation regulates the differentiation of Chondrocytes and osteoblasts.

关 键 词：O-GlcNAc糖基化 软骨细胞 成骨细胞 细胞分化 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学] R783[医药卫生—基础医学]