单纯疱疹病毒1型立即早期蛋白ICP22研究进展  

Research Progress on Herpes Simplex Virus 1 Immediately-early Protein ICP22

作　　者：陈韵颖 吴英 汪铭书[1,2,3] 程安春[1,2,3] CHEN Yunying;WU Ying;WANG Mingshu;CHENG Anchun;(College of Veterinary Medicine,Sichuan Agricultural University;Research Center of Avian Disease,College of Veterinary Medicine,Sichuan Agricultural University;Institute of Preventive Veterinary Medicine,Sichuan Agricultural University;Key Laboratory of Animal Disease and Human Health of Sichuan Province,Sichuan Agricultural University)

机构地区：[1]四川农业大学动物医学院禽病防治研究中心,成都611130 [2]四川农业大学预防兽医研究所,成都611130 [3]四川农业大学动物疫病与人类健康四川省重点实验室,成都611130 [4]四川农业大学动物医学院,成都611130

出　　处：《病毒学报》2018年第2期245-251,共7页Chinese Journal of Virology

基　　金：国家自然科学基金(项目号:31602079);题目:双拷贝ICP22对鸭瘟病毒转录调控的影响及功能位点解析;四川省教育厅重点项目(项目号:17ZA0309);题目:鸭瘟病毒单、双拷贝ICP22基因在病毒基因转录调控中的功能初探~~

摘　　要：单纯疱疹病毒1型（Herpes simplex virus 1,HSV-1）感染细胞蛋白22（Infected Cell Protein 22,ICP22）是Us1基因编码的一种翻译后修饰多功能蛋白,为HSV-1的五种立即早期蛋白之一。HSV-1ICP22能与不同的细胞和病毒成分相互作用来执行不同的功能,包括改变RNA聚合酶Ⅱ（RNA polymerase II,RNAPⅡ/PolⅡ）的磷酸化状态、参与抵抗细胞对病毒复制的消极作用、引起细胞周期蛋白A和B水平降低、介导修饰拓扑异构酶Ⅱα、参与胞核内病毒诱导的分子伴侣富集（Virus-induced chaperone-enriched,VICE）区域的形成及促进病毒新生核衣壳的初次包装。这些作用大多与调节病毒在胞核中有效复制相关。此外,HSV-1ICP22还在限制细胞中的病毒复制、病毒致病力和潜伏感染建立过程中发挥重要作用,但ICP22发挥这些作用的机制尚未知。本文就上述目前国内外对HSV ICP22的研究进展作一综述,以期为后续研究提供参考。Herpes simplex virus 1（HSV-1）infected cell protein 22（ICP22）,aposttranslational modified multifunctional protein encoded by the viral Us1 gene,is one of the five immediate-early proteins of HSV-1.HSV-1 ICP22 can interact with distinct cellular and viral components to perform different functions including altering the phosphorylation status of RNA polymerase Ⅱ（RNAPⅡ/PolⅡ）,participating in resisting the negative effects of cells upon viral replication,downregulating the expression of cyclin A and B,mediating the modification of topoisomerase IIa,being required for virus-induced chaperone-enriched（VICE）domain formation and inducing the primary envelopment of viral progeny nucleocapsids.Most of these functions are related to regulating effective replication of HSV-1 in the nucleus.ICP22 also plays significant roles in viral replication in restrictive cells,viral pathogenesis and establishment of latent infection.However,the mechanisms remain unknown.This article reviews recent research progresses on HSV-1 ICP22,hoping to provide references for future researches.

关 键 词：单纯疱疹病毒1型(HSV-1) 感染细胞蛋白22(ICP22) RNA聚合酶Ⅱ(PolⅡ) p53 细胞周期蛋白依赖性激酶1(cdk1) 病毒诱导的伴侣富集 核出芽 

分 类 号：R373.11[医药卫生—病原生物学]