脂肪来源干细胞治疗难愈性创面的研究进展  

Research progress of adipose-derived stem cells on refractory wounds

作　　者：熊佳超 宋建星[2] XIONG Jiachao1, SONG Jianxing2(1. Graduate School, the Second Military Medical University, Shanghai, 200433, P.R.China 2. Department of Plastic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, 200433, P.R.Chin)

机构地区：[1]第二军医大学研究生院,上海200433 [2]第二军医大学附属长海医院整形外科,上海200433

出　　处：《中国修复重建外科杂志》2018年第4期457-461,共5页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的总结近年脂肪来源干细胞(adipose-derived stem cells,ADSCs)应用于难愈性创面治疗中的研究进展。方法查阅近年有关ADSCs治疗难愈性创面的文献,分析总结其修复机制及治疗进展。结果 ADSCs与单支架技术、片材技术等方法联合应用促进难愈性创面愈合已取得巨大进展,ADSCs可通过自身旁分泌、促血管生成、抗氧化凋亡等多种机制,加快创面血管生成,促进难愈性创面愈合。结论 ADSCs来源充足,易提取且易培养,无免疫原性,具有多向分化潜能和显著的促血管生成潜能,已成为再生医学理想的种子细胞。但仍需提高干细胞传递技术,开发更有利于临床使用的生物材料,以提高难愈性创面的治愈率。Objective To summarize the recent advances in the research of adipose-derived stem cells （ADSCs） for the treatment of refractory wounds. Methods The related literature about using ADSCs for treating refractory wounds in recent years was reviewed, and their repair mechanism and treatment progress were summarized in detail. Results Tremendous progress has been achieved in using ADSCs in combination with single stent technology, sheet technology, and other methods to promote the healing of refractory wounds. ADSCs can accelerate wound angiogenesis and promote the healing of refractory wounds through its own mechanisms of paracrine, proangiogenic, anti-oxidative and apoptosis. Conclusion With the advantages of adequate sources, easy to extract and culture, non-immune rejection, multidirectional differentiation potential, and significant angiogenic potential, ADSCs has become the ideal seed cells of tissue regeneration. However, it is necessary to improve stem cell transmission technology and develop biomaterials for clinical application in order to improve the refractory wounds healing.

关 键 词：脂肪来源干细胞 难愈性创面 旁分泌 血管生成 支架 

分 类 号：R641[医药卫生—外科学]