激光热疗治疗小鼠肿瘤组织的温度仿真模型  

Temperature Simulation Model of Tumor Tissue in Tumor Bearing Mice during Photothermal Therapy

作　　者：龙珊 徐媛媛 周非凡 王博 曾亚超[4] 付艳[3] 胡佳 陈殿君[3] 杜楠[3] 李晓松[3] Long Shan1 , Xu Yuanyuan1 , Zhou Feifang2, Wang Bo 3, Zeng Yachao4 , Fu Yan3,Hu Jia3, Chen Dianjun3, Du Nan3, Li Xiaosong3(1 Training Base of Postgraduates, The First Affiliated Hospital of Chinese PLA General Hospital, Jinzhou Medical University, Beijing 100048,China; 2University of Central Oklahoma, Oklahoma 73034, USA , 3 Department of Ontology, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China 4 Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116000, Chin)

机构地区：[1]锦州医科大学附属中国人民解放军总医院第一附属医院研究生培养基地,北京100048 [2]美国中央俄克拉荷马大学,美国73034 [3]中国人民解放军总医院第一附属医院肿瘤二科,北京100048 [4]中科院大连化学物理研究所,辽宁大连116000

出　　处：《应用激光》2018年第1期142-149,共8页Applied Laser

基　　金：国家自然科学基金资助项目(项目编号:81572953)

摘　　要：目前应用激光热疗治疗肿瘤的研究比较多,但是激光联合光敏剂治疗肿瘤过程中肿瘤组织的三维温度分布的研究比较少。为了分析激光热疗过程中肿瘤及周围组织的三维温度分布情况,本实验首先运用红外热像仪监测激光联合吲哚菁绿治疗荷乳腺瘤小鼠过程中肿瘤表面的温度变化;其次,运用蒙特卡洛(Monte Carlo)原理模拟激光在生物组织中的光分布,进一步利用COMSOL Multiphysics构建激光热疗过程中肿瘤及周围组织温度的三维分布仿真模型。结果显示实际测量肿瘤表面最高点温度和仿真模拟肿瘤表面最高点温度分布吻合度较好;有光敏剂的肿瘤组织温度比没有光敏剂的肿瘤组织温度升高约20℃;模型中可见肿瘤组织不同部位温度可相差15℃左右。该模型可以分析肿瘤以及周围组织的温度时空分布情况,了解激光热疗治疗肿瘤的效果,该模型为激光热疗的应用提供参考作用。There are many studies about photothermal therapy for treatment of tumor. However, there are few studies about three-dimensional temperature distribution of tumor tissue during the treatment of laser combined with photosensitizer. This study aimed at constructing three-dimensional temperature distribution of tumor tissue in tumor bearing mice during the process of photothermal therapy. Firstly, the surface temperature of tumor tissue was monitored by near infrared thermometer during the treatment of laser combined with indocyanine green. Secondly, based on the Monte Carlo principle which could simulate la- ser light distribution in biological tissues, COMSOL Multiphysics analysis software was used to construct temperature distribu- tion simulation model of the tumor tissue during the photothermal therapy. The results revealed that the temperature measured during the photothermal therapy and the temperature calculated by simulation model are consistent. The temperature of tumor tissue with photosensitizer was higher about 20℃ than that without photosensitizer, The temperature elevation was about 15 ℃ between the high temperature part of tumor tissue and the low temperature part of tumor tissue. This simulation is capa- ble to analyze the spatial and temporal distribution of temperature in tumor tissues and surrounding tissues and holds great po- tential in the application of photothermal therapy.

关 键 词：激光热疗 温度分布 吲哚菁绿 蒙特卡洛 COMSOL Muhiphysics 

分 类 号：O439[机械工程—光学工程]