肥胖成年人血清胎球蛋白B水平与代谢综合征关系研究  

Association of serum Fetuin-B with metabolic syndrome in obese Chinese adults

作　　者：刘永文 王冬梅 李志斌 林明珠[1] 刘长勤[1] 陈政[1] 石秀林[1] 杨叔禹 李学军[1] Liu Yongwen, Wang Dongmei, Li Zhibin, Lin Mingzhu, Liu Changqin, Chen Zheng, Shi Xiulin, Yang Shuyu, Li Xuejun.(Department of Endocrinology and Diabetes, the First Affiliated Hospital of Xiamen University, Xiamen 361003, Chin)

机构地区：[1]厦门大学附属第一医院内分泌糖尿病科,361003 [2]厦门大学医学院 [3]厦门大学附属第一医院流行病学研究室 [4]厦门市糖尿病研究所

出　　处：《中华内分泌代谢杂志》2018年第3期217-222,共6页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的在肥胖成年人中检验血清胎球蛋白B（Fetuin-B）水平与代谢综合征的关系。方法横断面调查收集1 318名中心型肥胖的普通成人人口社会学、生活方式及临床数据，酶联免疫吸附法（ELISA）测定血清Fetuin-B水平，使用logistic回归分析Fetuin-B水平与代谢综合征及胰岛素抵抗的关系。结果820（62.2%）例研究对象为代谢综合征患者，其血清Fetuin-B水平比对照组人群显著升高[（4.18±1.39对4.02±1.35）μg/ml, P=0.043]。随着血清Fetuin-B水平的增加，空腹血糖和空腹胰岛素水平及非酒精性脂肪肝病（NAFLD）患病率、胰岛素抵抗比例均显著增加。多元logistic回归分析，经矫正混杂因素后，血清Fetuin-B水平可显著增加代谢综合征及胰岛素抵抗的风险（OR=1.19，95%CI 1.06-1.34, P=0.004；OR=1.15，95%CI 1.01-1.30, P=0.031）。结论血清Fetuin-B水平与NAFLD密切相关，血清Fetuin-B水平升高可显著增加代谢综合征患病风险。ObjectiveTo investigate the independent association of serum Fetuin-B with metabolic syndrome in obese Chinese adults.MethodsCross-sectional data on socio-demographic, lifestyle, clinical characteristics, and serum Fetuin-B were collected for 1 318 Chinese adults with central obesity. Associations of serum Fetuin-B with metabolic syndrome and insulin resistance were analyzed using multivariable Logistic regression analysis.ResultsA total of 820（62.2%）individuals were identified as metabolic syndrome. Subjects with metabolic syndrome showed significantly increased levels of serum Fetuin-B than those with non-metabolic syndrome [（4.18±1.39 vs 4.02±1.35）μg/ml, P=0.043]. Increased serum Fetuin-B were significantly associated with increased fasting plasma glucose and insulin levels, as well as prevalences of non-alcoholic fatty liver disease（NAFLD）and insulin resistance. After adjustment for potential confounders, serum Fetuin-B was significantly associated with increased risks of metabolic syndrome and insulin resistance（OR=1.19, 95%CI 1.06-1.34, P=0.004; OR=1.15, 95%CI 1.01-1.30, P=0.031 respectively）.ConclusionSerum Fetuin-B level was significantly associated with NAFLD; and elevated serum Fetuin-B was significantly associated with increased risk of metabolic syndrome.

关 键 词：胎球蛋白B 非酒精性脂肪肝病 代谢综合征 胰岛素抵抗 横断面研究 

分 类 号：R589[医药卫生—内分泌]