雌激素对中枢能量代谢的影响及其机制的研究进展  

Progress in the effects and machanism of central regulation of energy metabolism by estrogen

作　　者：李倩 温俊平[1] 陈刚[1] Li Qian, Wen Junping , Chen Gang.(Department of Endocrinology, Fujian Medical University, Fuzhou 350001, Chin)

机构地区：[1]福建医科大学省立临床医学院福建省立医院内分泌科,福州350001

出　　处：《中华内分泌代谢杂志》2018年第3期263-268,共6页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金项目（81170774、81770848）;福建省科技厅科技引导性项目（2015Y0008）;福建省卫生系统中青年骨干人才培养项目资助计划（2014-ZQN-ZD-1）;福建省科技创新联合资金项目（2016Y9006）

摘　　要：女性性激素如雌激素，参与调控许多生理过程，如生长、发育、生殖和新陈代谢等。雌激素参与众多的生理过程具有受体依赖性，主要通过雌激素受体（ER）发挥作用。ER可分为ERα和ERβ两种类型，广泛分布于中枢和外周组织。近年来越来越多证据显示雌激素主要是在中枢神经系统尤其是下丘脑发挥各种生物学作用，表明中枢ER在雌激素调控的生理病理过程中起重要作用。本文将回顾雌激素在能量代谢方面的作用，尤其关注下丘脑部位的能量代谢作用，为生殖、能量代谢相关性疾病寻找中枢药物治疗的靶点。Sex hormones such as estrogen in females may play prominent roles in the control of numerous physiological process including growth, development, reproduction, and metabolism. The effects of estrogen are receptor dependent. Estrogen receptor （ER） have two main forms, ERα and ERβ, which were widely distributed in the central and peripheral tissues. Recently, more and more data have shown that the central estrogen via ER play a critical role in the regulation of various biological effects including physiological and pathological process. This article will review the role of estrogen on energy metabolism, especially in hypothalamus, in order to find the target sites of the central estrogen responsible for the diseases related to reproduction and energy metabolism.

关 键 词：雌激素 能量代谢 下丘脑 

分 类 号：R588[医药卫生—内分泌]