基于分子印迹技术的左旋延胡索乙素微球的制备及体外释药研究  

Preparation and Release Studies of L-Tetrahydropalmatine Microspheres Based on Molecular Imprinting Technique

作　　者：李博[1] 朱俊访[1] 聂阳 LI Bo1 ,ZHU Jun-fang1 ,NIE Yang2(1. Guangdong Food and Drug Vocational College, Guangzhou 510520, China; 2. Traditional Chinese Medical Institute of Guangdong Province, Guangzhou 510520, Chin)

机构地区：[1]广东食品药品职业学院,广东广州510520 [2]广东省中药研究所,广东广州510520

出　　处：《中药材》2017年第9期2138-2140,共3页Journal of Chinese Medicinal Materials

基　　金：广东省医学科学技术研究基金项目(A2015470);广东省中医药局科研项目(20162027)

摘　　要：目的:利用分子印迹技术制备左旋延胡索乙素(L-THP)微球。方法:以L-THP为模板分子,甲基丙烯酸(MAA)为功能单体,乙二醇二甲基丙烯酸酯(EDMA)为交联剂,使用沉淀聚合法制备L-THP微球,并考察该微球的吸附能力和在模拟胃液中的释药性能。结果:L-THP印迹微球能特异性地吸附L-THP,最大吸附量可达1.97μmol/g,分子印迹聚合物在模拟胃液中5 h内表现出明显的药物缓释能力。结论:L-THP印迹微球对L-THP具有良好的吸附能力和一定的缓释能力。Objective： To prepare the sustained release microspheres of L-tetrahydropalmatine（ L-THP） by the molecular imprinting technique. Methods： L-THP was used as template,methyl acrylic acid（ MAA） was used as functional monmer,ehtylene glycol dimethacrylate（ EDMA） was used as a cross-linking agent to prepare the sustained release microspheres. L-THP microspheres was prepared by precipitation polymerization,and a test was conducted to investigate the performance of adsorption and drug controlled release in artificial gastric juice. Results： The experiment showed that the sustained release microspheres had specific adsorption to L-THP,the adsorption capacity was up to 1. 97 μmol/g,the molecular imprinted polymers（ MIPs） microspheres had obvious drug release capacity in artificial gastric juice in 5 h. Conclusion： The sustained release microspheres have a good adsorption and drug controlled release performance of L-THP.

关 键 词：分子印迹技术 微球 左旋延胡索乙素 分子印迹聚合物 

分 类 号：R283.6[医药卫生—中药学]