AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C elegans  

作　　者：Jiajun Fu Haining Zhang Wenming Huang Xinyu Zhu Yi Sheng Eli Song Tao Xu 

机构地区：[1]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute ofBiophysics, Chinese Academy of Sciences, Beijing 100101, China [2]Coliege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China [3]Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology,Huazhong University of Science and Technology, Wuhan 430074, China

出　　处：《Biophysics Reports》2018年第1期17-24,共8页生物物理学报（英文版）

摘　　要：Feeding behavior is the most fundamental behavior in C. elegans. Our previous results have dissected the central integration circuit for the regulation of feeding, which integrates opposing sensory inputs and regulates feeding behavior in a nonlinear manner. However, the peripheral integration that acts downstream of the central integration circuit to modulate feeding remains largely unknown. Here, we find that a Gαi/o-coupled tyramine receptor, TYRA-2, is involved in peripheral feeding suppression. TYRA-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit. Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior.Feeding behavior is the most fundamental behavior in C. elegans. Our previous results have dissected the central integration circuit for the regulation of feeding, which integrates opposing sensory inputs and regulates feeding behavior in a nonlinear manner. However, the peripheral integration that acts downstream of the central integration circuit to modulate feeding remains largely unknown. Here, we find that a Gαi/o-coupled tyramine receptor, TYRA-2, is involved in peripheral feeding suppression. TYRA-2 suppresses feeding behavior via the AIM interneurons, which receive tyramine/octopamine signals from RIM/RIC neurons in the central integration circuit. Our results reveal previously unidentified roles for the receptor TYRA-2 and the AIM interneurons in feeding regulation, providing a further understanding of how biogenic amines tyramine and octopamine regulate feeding behavior.

关 键 词：C. elegans TYRA-2 receptor AIM interneurons Peripheral feeding regulation TYRAMINE 

分 类 号：Q42[生物学—神经生物学]