幽门螺杆菌经呼吸道传播的设想  

Helicobacter pylori may be transmitted by respiratory droplet: a medical hypothesis

作　　者：司小北[1] 蓝宇[1] 高岩[1] SI Xiaobei, LAN Yu, GAO Yan(Department of Gastroenterology, Beijing Jishuitan Hospital, Beijing 100035, Chin)

机构地区：[1]北京积水潭医院消化内科,北京100035

出　　处：《医学争鸣》2018年第2期14-17,21,共5页Negative

摘　　要：幽门螺杆菌(H.pylori)是一类广泛定植于胃黏膜的微需氧革兰阳性杆菌。目前,关于H.pylori传播的机制尚不甚清楚。人对人途径和经水源途径是两种可能的传播途径。除此之外,H.pylori还有可能经呼吸道传播。推测经呼吸道传播H.pylori可能包含以下过程:第一步,胃食管反流液将H.pylori从胃黏膜带入食管;第二步,H.pylori经过微误吸的方式被带入呼吸道并定植于其表面;第三步,定植于呼吸道的H.pylori以飞沫携带的方式呼出感染者体外;第四步,携带H.pylori的飞沫被健康人群吸入并定植于其呼吸道;第五步,胃食管反流液将定植于呼吸道的H.pylori带入消化道。Helicobacter pylori （H. pylori） is a microaerophilic gram-positive bacterium that mainly colonizes humangastric mucosa and causes a long-term immune response. The mechanism of H. pylori transmission is still not completelyunderstood. The person-to-person and waterborne transmission pathways are the most probable pathways of H. pyloritransmission. We hypothesize that H. pylori might also be transmitted via respiratory tract. The mechanism is as follows：Step 1, the reflux fluids from stomach takes H. pylori to esophagus and throat; step 2, H. pylori colonizes the surface ofupper respiratory tract by microaspiration; step 3, H. pylori that colonizes respiratory tract is exhaled via droplets afterexpiratory events; step 4, the droplets with H. pylori were inhaled by the susceptible persons and H. pylori may colonizethe respiratory tract; step 5, the reflux fluids from stomach bring H. pylori on the surface of respiratory tract into digestivetract.

关 键 词：幽门螺杆菌 传播 呼吸道飞沫 

分 类 号：R37[医药卫生—病原生物学]