发作性睡病中医证候研究概况  

Research situation about traditional Chinese medicine syndrome types of narcolepsy

作　　者：董园莉[1] 王朋 李玫[3] 戴中[1] 冯淬灵[1] 王少杰[1] DONG Yuan-li;WANG Peng;LI Mei;DAI Zhong;FENG Cui-ling;WANG Shao-jie(Department of Traditional Chinese Medicine, Peking University People＇ s Hospital, Beijing 100044, China;The Fourth Department of Healthcare, China-Japan Friendship Hospital, Beijing 100029, China;Institute of Clinical Molecular Biology, Peking University People＇s Hospital, Beijing 100044, China)

机构地区：[1]北京大学人民医院中医科,北京100044 [2]中日友好医院保健部四部,北京100029 [3]北京大学人民医院临床分子生物学研究所,北京100044

出　　处：《中华中医药杂志》2018年第4期1452-1455,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金青年项目(No.81503519);国家自然科学基金面上项目(No.81273712);北京大学人民医院研究与发展基金项目(No.RDB2015-18;No.RDC2012-22)~~

摘　　要：发作性睡病在国际上的研究已比较深入,而国内研究尚在起步阶段,该病的发病率呈上升趋势。目前发作性睡病的中医证候分类尚未规范统一,准确的辨证有助于提高中医药临床疗效。文章从证候分类、不同分型的证候分布特点及证候与HLA-DQB1易感基因相关性等方面概括发作性睡病证候研究。结果发现发作性睡病的证候分类主要为单证证候和复合证候,证候在早发型和晚发型有不同的分布特点,证候与HLA-DQB1易感基因存在相关性。在前期研究基础上,应尽快建立规范化的发作性睡病证候标准,指导中医药治疗发作性睡病的临床和基础研究。The study of narcolepsy is very comprehensive abroad while initial at home. The incidence rate of narcolepsy has risen in recent years. Appropriate syndrome differentiation develops the clinical effect of traditional Chinese medicine （TCM） in treating narcolepsy, while the criterion of the TCM syndrome classification of narcolepsy has not been established at present. Syndrome researches of narcolepsy were summarized from the following aspects, such as syndrome classification, characteristics of TCM syndrome type distribution in different disease types, relationship between syndrome and the susceptible gene of HLA- DQB 1. The study concluded that the syndrome classification of narcolepsy mainly includes single or composite syndromes, syndrome distribution bad different characteristics between early-onset and late-onset narcolepsy. Besides, syndrome and the susceptible gene of HLA-DQB 1 were correlations. Standards for syndromes of narcolepsy should be established recently based on previous research for providing guidance in clinical and basic research on TCM treatment of narcolepsy.

关 键 词：发作性睡病 证候分类 证候分布 早发型发作性睡病 晚发型发作性睡病 HLA-DQB1易感基因 

分 类 号：R277.7[医药卫生—中医学]