消瘀散对骨关节炎患者Th细胞因子、PAF/PAF-AH、TXB2/6-keto-PGF1α的影响  

Effects of Xiaoyu Powder on Th cytokines, PAF/PAF-AH and TXB2/6-keto-PGF1α in patients with osteoarthritis

作　　者：万磊[1] 刘健[1] 黄传兵[1] 张皖东[1] 章平衡 黄旦[2] WAN Lei;LIU Jian;HUANG Chuan-bing;ZHANG Wan-dong;ZHANG Ping-heng;HUANG Dan(The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230031, China;Anhui University of Chinese Medicine, Hefei 230038, China)

机构地区：[1]安徽中医药大学第一附属医院,合肥230031 [2]安徽中医药大学,合肥230038

出　　处：《中华中医药杂志》2018年第4期1634-1637,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81403388);国家临床重点专科中医风湿病科开放基金项目(No.LCZDZKKFJJ001);安徽省自然科学基金项目(No.1508085QH159);安徽省重点实验室:现代中医内科应用基础与开发研究项目(No.1606c08238);安徽省高校自然科学基金重点项目(No.KJ2017A281)~~

摘　　要：目的:观察消瘀散对骨关节炎患者Th细胞因子、血小板活化因子(PAF)/血小板活化因子-乙酰水解酶(PAF-AH)、血栓素B2(TXB2)/6-酮-前列腺素F1α(6-keto-PGF1α)的影响。方法:选取60例骨关节炎患者,随机分为研究组(消瘀散外敷、氨基葡萄糖口服)、对照组(氨基葡萄糖口服),8周后观察两组实验室指标、Th细胞因子及血瘀状态指标的变化。结果:治疗8周后,研究组显效率明显高于对照组(P<0.05)。与对照组比较,研究组在降低关节刺痛、关节僵硬、皮下瘀斑、血瘀状态总积分方面优于对照组(P<0.05);与治疗前比较,研究组治疗后血沉(ESR)、C反应蛋白(CRP)、血小板(PLT)、D-二聚体(D-D)、纤维蛋白原(FIB)、白细胞介素(IL)-1、IL-17、PAF、TXB2明显降低(P<0.05,P<0.01),IL-4、IL-10、PAF-AH、6-keto-PGF1α明显升高(P<0.01)。治疗后,与对照组比较,研究组PLT、FIB、IL-17、TXB2降低(P<0.05),6-keto-PGF1α升高(P<0.05)。结论:消瘀散调节Th细胞因子动态平衡,从而抑制IL-1、IL-17表达,调节血栓素/前列腺素平衡,改善骨关节炎血瘀状态。Objective： To observe the effects of Xiaoyu Powder on Th cell cytokines, platelet activating factor （PAF）/ platelet activating factor-acetylhydrolase（PAF-AH）, thromboxane B2 （TXB2）/6-keto-prostaglandin Flct （6-keto-PGF1 tx ） in patients with osteoarthritis. Methods： Sixty patients with osteoarthritis were randomly divided into study group （Xiaoyu Powder, glucosamine） and control group （glucosamine）. After 8 weeks, the changes of laboratory indexes, Th cytokines and blood stasis status indicators were observed. Results： After 8 weeks of treatment, the markedly effective rate in the study group was significantly higher than that in the control group （P〈0.05）. Compared with the control group, the study group was superior to the control group in reducing the total score of joint tingling, joint stiffness, subcutaneous ecchymosis and blood stasis status （P〈0.05）. Compared with before treatment, the ESR, C-reactive protein （CRP）, platelet （PLT）, D-dimer （D-D）, fibrinogen （FIB）, interleukin （IL）-1, IL-17, PAF and TXB2 were significantly decreased （P〈0.05, P〈0.01）, while IL-4, IL-10, PAF-AH and 6-keto-PGF1 a were significantly increased （P〈0.01）. After treatment, compared with the control group, the levels of PLT, FIB, IL-17 and TXB2 were decreased （P〈0.05） and 6-keto-PGF1α were increased （P〈0.05）. Conclusion： Xiaoyu Powder can regulate the dynamic balance of Th cytokines, thereby inhibiting the expression of IL-1 and IL-17, regulating the balance of thromboxane/prostaglandin and improving the blood stasis of osteoarthritis.

关 键 词：骨关节炎 消瘀散 TH细胞因子 血小板活性因子/血小板活化因子-乙酰水解酶 血栓素B2/6-酮-前列腺素F1α 

分 类 号：R274.9[医药卫生—中西医结合]