基于内质网应激角度探讨中医脾虚本质  

Essence of Spleen Deficiency Syndrome from Endoplasmic Reticulum Stress

作　　者：吕林[1] 唐旭东[1] 王凤云[1] 尹晓岚 石啸双 段园志 谢璟仪 张敏[2] LYU Lin;TANG Xudong;WANG Fengyun;YIN Xiaolan;SHI Xiaoshuang;DUAN Yuanzhi;XIE Jingyi;ZHANG Min(Digestive Department,Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing Institute of Spleen and Stomach Disease of Traditional Chinese Medicine, Beijing 100091 ,China;Graduate School of China Academy of Chinese Medical Sciences, Beijing 100700, China;Graduate School of Beijing University of Chinese Medicine, Beijing 100029, China)

机构地区：[1]中国中医科学院西苑医院脾胃病科北京市中医脾胃病研究所,北京100091 [2]中国中医科学院研究生院,北京100700 [3]北京中医药大学研究生院,北京100029

出　　处：《中华中医药学刊》2018年第4期819-823,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)项目(2013CB531703);国家自然科学基金项目(81503567);中国博士后科学基金项目(2015M1227,2016T90195)

摘　　要：从细胞内质网应激角度探讨中医脾虚的科学内涵。介绍内质网的结构与功能、内质网应激的机制以及内质网应激导致的各种疾病,结合中医脾虚证所致各种临床疾病,对中医脾虚证的现代研究情况进行了分析,目前脾虚证本质的研究尚存在一些不足之处,提出了内质网与中医脾的藏象功能联系最大,内质网应激可能是中医脾虚本质的客观指标之一。This paper discusses the scientific connotation of spleen-deficiency syndrome from the perspective of endoplasmic reticulum stress. It introduces the structure and function of endoplasmic reticulum,the effects of endoplasmic reticulum stress caused by various factors,as well as various diseases caused by endoplasmic reticulum stress. On the basis of various diseases caused by spleen-deficiency syndrome,it analyzs the modern research on spleen-deficiency syndrome of TCM and finds out that the present study the essence of spleen-deficiency still has some shortcomings. It concludes that endoplasmic reticulum has the closest relationship with the function of the＂spleen＂in Chinese medicine and that endoplasmic reticulum stress may essentially be one of the objective indicator of TCM spleen-deficiency.

关 键 词：内质网 内质网应激 脾虚证 中医 

分 类 号：R2-03[医药卫生—中医学]