复方七芍降压片对SHR氧化应激及p22phox蛋白表达的影响  

Effect of Compound Qishao Jiangya Tablets on Oxidative Stress of Spontaneously Hypertensive Rats and Expression of p22phox Protein

作　　者：雍苏南 卿俊 谭元生 YONG Sunan;QING Jun;TAN Yuansheng(The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan, China)

机构地区：[1]湖南中医药大学第一附属医院

出　　处：《中华中医药学刊》2018年第4期856-858,I0008,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81473616);湖南省科技计划项目(2013SK2025);湖南省中医药科研计划重点项目(201403)

摘　　要：目的：观察复方七芍降压片对SHR氧化应激的减弱作用。方法：48只SHR按血压分层随机分为4组,即模型组（SHR-M）、厄贝沙坦组（SHR-E）、低剂量治疗组（SHR-D）、高剂量治疗组（SHR-G）,每组12只,12只WKY大鼠为空白对照组。连续灌胃12周,观察SHR胸主动脉血浆SOD、血清MDA和ROS以及胸主动脉p22phox蛋白的表达的变化。结果：与空白对照组比较,SHR各组血浆SOD明显降低,血清MDA、ROS水平明显升高,胸主动脉p22phox蛋白表达量明显升高,差异有统计学意义（P〈0.05）。结论：复方七芍降压片通过上调血浆SOD水平,降低血清MDA、ROS浓度,改善SHR氧化应激状态,从而达到降低血压的作用。Objective： To explore the mechanism of Compound Qishao Jiangya Tablets（ FFQSJYP） on lowering blood pressure of spontaneously hypertensive rats and the effect on oxidative stress. Method： Tweleve 8-week-old normal Wistar-kyoto（ WKY） rats were used as normal group and 48 8-week-old spontaneously hypertensive rats（ SHR） were divided into 4 groups at random： model group,Irbesartan Tablets group（ 6. 75 mg · kg^（-1）·d^（-1））,low-dose treatment group（ 21. 6 mg·kg^（-1）·d^（-1））,high-dose treatment group（ 86. 4 mg·kg^（-1）·d^（-1））. 12 weeks later,we explored the effect on oxidative stress and the expression of p22 phox protein. Results： Compared with the normal group,the plasma ROS was dropped（ P 〈0. 01）; the MDA and ROS in serum sharply increased（ P 〈0. 05）; the p22 phox protein expression on the thoracic aortic sharply increased（ P 〈0. 01）. After the treatment of FFQSJYP,the p22 phox protein expression on the thoracic aortic and oxidative stress were dropped（ P 〈0. 01）,which also appeared dose-dependent manner.Conclusion： FFQSJYP had a significant decrease of blood pressure and mechanism might be to improve oxidative stress.

关 键 词：复方七芍降压片 SHR 氧化应激 p22phox蛋白 

分 类 号：R285.5[医药卫生—中药学]