失功能高密度脂蛋白结构改变及功能变化  

Structural Changes and Functional Changes of Dysfunction High Density Lipoprotein

作　　者：李玉杰[1] 李宁 张会永[3] 姜钧文[3] LI Yujie;LI Ning;ZHANG Huiyong;JIANG Junwen(Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China;Shenyang Disabled Persons＇ Federation, Shenyang 110031 ,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning, China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]沈阳市残疾人联合会,辽宁沈阳110031 [3]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中华中医药学刊》2018年第4期903-907,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81603513);辽宁省自然科学基金项目(2015020385)

摘　　要：研究发现功能性高密度脂蛋白（HDL）主要具有胆固醇逆转运（RCT）、抗炎、抗氧化、抗血栓、促纤溶以及改善内皮细胞功能等生物学活性,而当机体处于急性反应阶段、慢性炎症及一些代谢性疾病时,其内环境紊乱,HDL被病理性修饰,导致失去了原有的功能,甚至表现出相反的作用,加速了动脉粥样硬化（AS）的进展以及心血管急性事件的发生率,以往人们只单纯的认为HDL失去功能是由于其＂量＂发生了变化,而近些年,研究者通过不断深入、细致的研究,发现HDL失去其功能不但是＂量＂的变化,更主要的是HDL的＂质＂发生了改变。中医认为血脂异常患者多由脾虚导致,脾虚运化失常,日久在体内易于形成痰浊,临床对于这类患者可以应用健脾化痰降浊之法来改善血脂异常的问题。The study has found that the function of high density lipoprotein（ HDL） can reverse cholesterol transport（ RCT）,anti-inflammatory,antioxidant,anti thrombosis,fibrinolysis and improve endothelial cell function and biological activity,and when the body is in the acute phase,chronic inflammation and some metabolic diseases or disorders of the environment,HDL can be pathologically modified resulting in the loss of the original function,and even showing the opposite effect,accelerated atherosclerosis（ AS） and the progress of acute cardiovascular events. In the past,people only think HDL loss of function is due to its quantity has changed. But in recent years,in-depth research and detailed study has found that HDL losing its function is not only due to the quantity change,but more important is the change of quality of HDL. Traditional Chinese medicine believes that the patients with dyslipidemia are mostly caused by spleen deficiency,and the spleen deficiency is abnormal. It is easy to form phlegm in the body in a long time. For those patients,we can apply the method of invigorating the spleen,reducing phlegm and turbidity to improve the problem of dyslipidemia.

关 键 词：失功能高密度脂蛋白(DyHDL) 血清淀粉样蛋白(SAA) 1-磷酸鞘氨醇(S1P) 髓过氧化物酶(MPO) 对氧磷酶1(PON1) 

分 类 号：R285.5[医药卫生—中药学]