滋肾补肺汤辅助西药对症干预治疗特发性肺间质纤维化继发慢性呼吸衰竭临床研究  被引量:13

Clinical Study of Zishen Buyin Decoction Assisted with Western Medicine Symptomatic Intervention in Treatment of Patients with Chronic Respiratory Failure Secondary to Idiopathic Pulmonary Fibrosis

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作  者:陶红卫 陆学超 姜洪玉 周佩夏 冷眉 赵玲 刘怡 TAO Hongwei;LU Xuechao;JIANG Hongyu;ZHOU Peixia;LENG Mei;ZHAO Ling;LIU Yi(Tuberculosis Department, Haici Medical Group in Qingdao, Qingdao 266033, Shandong, Chin)

机构地区:[1]青岛市海慈医疗集团肺病科

出  处:《中华中医药学刊》2018年第4期946-948,共3页Chinese Archives of Traditional Chinese Medicine

基  金:山东省中医药科技发展计划项目(2011-258);青岛市民生科技计划项目(KJZD-14-14-NSH)

摘  要:目的:探讨滋肾补肺汤辅助西药对症干预治疗特发性肺间质纤维化继发慢性呼吸衰竭临床效果。方法:研究对象选取医院2015年4月—2016年12月收治特发性肺间质纤维化继发慢性呼吸衰竭患者共58例,以随机数字表法分为对照组(29例)和中医组(29例),分别采用西药对症干预和在此基础上加用自滋肾补肺汤辅助治疗;比较两组患者临床疗效,治疗前后中医证候积分、呼吸频率、心率、血气分析指标水平及不良反应发生率。结果:中医组患者治疗总有效率显著高于对照组(P〈0.05)。结论:滋肾补肺汤辅助西药对症干预治疗特发性肺间质纤维化继发慢性呼吸衰竭可有效减轻呼吸道症状体征,降低呼吸频率和心率,改善血气分析指标水平,且未加重药物不良反应。Objective: To investigate the clinical effects of Zishen Buyin Decoction assisted with western medicine symptomatic intervention in the treatment of patients with chronic respiratory failure secondary to idiopathic pulmonary fibrosis. Methods: Fifty-eight patients with chronic respiratory failure secondary to idiopathic pulmonary fibrosis were chosen from April 2015 to December 2016 in our hospital and randomly divided into two groups including control group( 29 patients) with western medicine symptomatic intervention and TCM group( 29 patients) with Zishen Buyin Decoction on the basis of control group; and the clinical effects,the TCM syndrome score,respiratory rate,heart rate and blood gas analysis index before and after treatment and the incidence of adverse reactions of both groups were compared. Results: The clinical effects of TCM group were significant better than that of the control group( P 〈 0. 05). The TCM syndrome score,respiratory rate and heart rate after treatment of TCM group were significant lower than those of the control group and before treatment( P 〈 0. 05). The levels of SaO_2,PaO_2,PaCO_2,HCO_3 and p H after treatment of TCM group were significant lower than those of the control group and before treatment( P 〈 0. 05). There was no significant difference in the incidence of adverse reaction between 2 groups( P 〉 0. 05). Conclusion: Zishen Buyin Decoction assisted with western medicine symptomatic intervention in the treatment of patients with chronic respiratory failure secondary to idiopathic pulmonary fibrosis can efficiently relieve the respiratory symptoms and signs,reduce the respiratory rate and heart rate,improve the levels of blood gas analysis index and does not aggravate adverse drug reactions.

关 键 词:中医药 特发性肺间质纤维化 慢性呼吸衰竭 疗效 

分 类 号:R563.8[医药卫生—呼吸系统]

 

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