北京社区人群双上臂收缩压差与颈动脉硬化的关系  

Relationship between inter arm systolic blood pressure difference and carotid atherosclerosis in a Beijing community population

作　　者：马为[1] 张宝娓[1] 杨颖[1] 齐丽彤[1] 孟磊[1] 张岩[1] 于扬[1] 朱赛楠[2] 霍勇[1] MA Wei , ZHANG Bao-wei, YANG Ying, QI Li-tong, MENG Lei, ZHANG Yah, YU Yang, ZHU Sai-nan, HUO Yong(Department of Cardiology, Peking University First Hospital, Beijing 100034, Chin)

机构地区：[1]北京大学第一医院心内科,北京100034 [2]北京大学第一医院医学统计室,北京100034

出　　处：《中华高血压杂志》2018年第2期150-154,共5页Chinese Journal of Hypertension

基　　金："十一五"科技支撑计划(2006BAI01A02)

摘　　要：目的分析北京社区人群中双上肢收缩压差(IASBPD)与颈动脉硬化的关系。方法 2007年9到12月在北京石景山区苹果园社区卫生服务中心进行临床调查,选取研究对象1426人,采用无创疾病筛检仪VP1000进行双上肢血压同步测量。IASBPD定义为左上肢收缩压与右上肢收缩压差值的绝对值,IASBPD≥10 mm Hg定义为IASBPD增高。同时测量颈动脉内膜中层厚度(IMT)及颈动脉斑块和其他心血管病危险因素。分析IASBPD增高与颈动脉硬化的关系。结果与IASBPD<10mm Hg组(n=1276)相比,IASBPD≥10mm Hg组(n=150)颈动脉IMT最大值(IMT_(max))(0.96比0.90 mm,P<0.05)、颈动脉窦部IMT_(max)(0.91比0.87,P<0.05)以及颈内动脉IMT_(max)(0.66比0.62,P<0.05)均增加。多因素Logistic回归分析显示,女性[OR(95%CI)为0.42(0.30~0.58),P<0.01]与劲动脉硬化负相关。年龄[1.08(1.07~1.09),P<0.01]、低密度脂蛋白胆固醇(LDL-C)升高[1.80(1.07~3.04),P<0.05]、高血压[1.68(1.27~2.23),P<0.01]、吸烟[1.47(1.05~2.08),P<0.05]与颈动脉硬化正相关。IASBPD≥10mm Hg与颈动脉硬化无关[1.15(0.76~1.73),P=0.52]。结论社区人群中IASBPD增高与颈动脉硬化非独立相关。Objective To examine the relationship between inter arm systolic blood pressure difference（fASBPD）and carotid atherosclerosis. Methods A total of 1426 individuals from Pingguoyuan community health service center of Shijingshan District in Beijing were enrolled from September to December 2007. The blood pressures were assessed on both arms simultaneously with a VP-1000. IASBPD was defined as the absolute value of difference in systolic blood pressure between left and right upper arm （｜ R - L｜ ）. IASBPD ≥10 mm Hg was considered IASBPD in- crease. Carotid intima-media thickness （IMT） and plaques were measured along with other cardiovascular disease risk factors. The relationship between IASBPD and carotid atherosclerosis was analyzed. Results Carotid IMTmax （0.96 vs 0.90, P〈0.05）, Carotid sinus IMTmax （0.91 vs 0.87, P〈0.05）and internal carotid IMTmax （0.66 vs0.6Z, P〈0.05） in IASBPD≥10 mm Hg group （n= 150） were higher than IASBPD〈10 mm Hg group （n= 1276）. Multivariate Logistic regression analysis showed that the female gender was negatively related with ca- rotid atherosclerosis [-OR （95% CI） 0. 42（0.30-0.58）, P〈0.01], while age （1.08（1.07-1.09）, P〈0.01], low density lipoprotein cholesterol increasing （1.80（ 1.07- 3.04 ）, P〈0.05], hypertension [1.68 （ 1.27 -2.23 ）, P〈 0.01] and smoking [1.47（ 1.05-2.08）, P〈0.05] were positively related with carotid atherosclerosis. IASBPD ≥10 mm Hg was not related with carotid atherosclerosis [1.15 （ 0.76- 1.73 ）, P= 0.52]. Conclusion IASBPD ≥10 mm Hg was not independently related with carotid atherosclerosis in this community population.

关 键 词：颈动脉 动脉硬化 双上肢收缩压差 

分 类 号：R543.4[医药卫生—心血管疾病]