基因拷贝数变异与汉、维、哈三民族儿童超重/肥胖患病风险之间的关联研究  

Association between copy number variations and risk of overweight/obesity among Han,Uyghur,and Kazak children

作　　者：阿比旦.艾尼瓦尔 阿达力别克[1] 黄冰雪[1] 叶.叶克吉尔格力 窦亚兰 吴洁[4] 戴江红[1] ABIDAN＇Ainiwaer, Adalibieke, HUANG Bing-Xue, YE Yekejiergeli, DOU Ya-Lan, WU Jie, DAI Jiang-Hong(Department of Epidemiology and Health Statistics, College of Public Health, Xinjiang Medical University, Urumqi 830011, China)

机构地区：[1]新疆医科大学公共卫生学院流行病学与卫生统计学教研室,新疆乌鲁木齐830011 [2]新疆乌鲁木齐市头屯河区疾病预防控制中心,新疆乌鲁木齐830023 [3]复旦大学附属儿科医院,上海201107 [4]新疆医科大学附属肿瘤医院,新疆乌鲁木齐830011

出　　处：《中国当代儿科杂志》2018年第4期308-313,共6页Chinese Journal of Contemporary Pediatrics

基　　金：国家自然科学基金(81260440)

摘　　要：目的了解新疆汉族、维吾尔族(简称维族)、哈萨克族(简称哈族)儿童超重/肥胖患病情况与基因拷贝数变异(CNV)之间的关系。方法以新疆伊犁、阿勒泰和克拉玛依3个城市中的幼儿园作为研究现场,采用分层整群抽样方法抽取3~7岁儿童,测量身高、体重并采集口腔黏膜脱落细胞,采用CNVplex~?方法检测FTO_1、IRX3_1、IRX3_2、MC4R_1、MC4R_2等5个位点CNV。结果调查儿童603名,其中男307名,女296名;汉族261名,维族194名,哈族148名。汉族、维族、哈族儿童超重/肥胖率分别为28.3%、10.3%、31.1%(P<0.001)。在哈族儿童中,IRX3_1、MC4R_2两位点CNV与超重/肥胖相关(P<0.05)。多因素logistic回归分析显示,汉族和哈族儿童发生超重/肥胖的风险分别是维族儿童的3.443倍(95%CI:2.016~5.880)和3.924倍(95%CI:2.199~7.001);IRX3_1位点CNV是超重/肥胖的危险因素(P=0.028,OR=2.251,95%CI:1.418~5.651)。结论 IRX3_1 CNV与汉族、维族、哈族儿童超重/肥胖的患病风险有关,尤其应关注哈族儿童中IRX3_1 CNV与超重/肥胖之间的关联性。Objective To study the association between the prevalence of overweight/obesity and copy number variations（CNVs） among Han, Uyghur, and Kazak children in Xinjiang, China. Methods The kindergartens in Ili, Altay, and Karamay in Xinjiang were selected as research sites, and stratified cluster sampling was used to select the children aged 3-7 years. Body height and body weight were measured, and exfoliated buccal mucosa cells were collected. CNVplex~？ was used to measure the CNVs of FTO1, IRX31, IRX32, MC4R1, and MC4R2. Results A total of 603 children were surveyed（307 boys and 296 girls）. There were 261 Han children, 194 Uyghur children, and 148 Kazak children. The overweight/obesity rates in Han, Uyghur, and Kazak children were 28.3%, 10.3%, and 31.1%, respectively（P0.001）. In Kazak children, the CNVs of IRX31 and MC4R2 were associated with overweight/obesity（P0.05）. The multivariate logistic regression analysis showed that the risk of overweight/obesity in Han and Kazak children was 3.443 times（95%CI： 2.016-5.880） and 3.924 times（95%CI： 2.199-7.001）, respectively, that in Uyghur children. The CNV of IRX31 was a risk factor for overweight/obesity（P=0.028, OR=2.251, 95%CI： 1.418-5.651）. Conclusions The CNV of IRX31 is associated with overweight/obesity in Han, Uyghur, and Kazak children, and the association between the CNV of IRX31 and overweight/obesity in Kazak children should be taken seriously.

关 键 词：基因拷贝数变异 肥胖 哈萨克族 儿童 

分 类 号：R723.14[医药卫生—儿科]