猪链球菌2型毒力因子研究新进展  

New Progress in the Study of Streptococcus suis Type 2 Virulence Factors

作　　者：刘静贤 何欣[1] 韩慧明[1,2] LIU Jing-xian1 HE Xin1 HAN Hui-ming1,2(1 Basic Medical College, Beihua University, Jilin 132013, China） （2 The Clinical Immunology Research Center, Beihua University, Jilin 132013, China)

机构地区：[1]北华大学基础医学院,吉林132013 [2]北华大学基础医学院临床免疫研究中心,吉林132013

出　　处：《中国生物工程杂志》2018年第3期97-104,共8页China Biotechnology

基　　金：吉林省教育厅科学技术研究项目(2015146)资助项目

摘　　要：猪链球菌是一种传染性革兰氏阳性菌,是严重影响养猪业发展的重要人畜共患病原体,造成人类死亡率在5%~20%。其毒力因子在致病过程中发挥着重要作用。近年来对猪链球菌2型的毒力因子研究有诸多新的进展,对其致病机制的了解和对该病有效防控都有新的认识。对近些年研究2型猪链球菌毒力相关因子,对蛋白质类、酶类研究的新进展,同时对毒力因子基因表达双组分系统、与宿主免疫系统相互作用的Ⅳ型分泌系统的进展进行总结和分析,以期为猪链球菌病的治疗和疫苗的研制提供新参考。Streptococcus suis is an infectious Gram-positive bacterium. Streptococcus suis serotype 2（ S. suis2,SS2） is an important zoonotic pathogen that severely affects the swine breeding industry and causes human mortality rates of between 5% and 20%. Its virulence factors play an important role in the pathogenesis. In recent years,there were many new advances in the virulence factors of SS2. in the pathogenic mechanism,and there were either new knowledge for effective prevention and control of the disease. The recent progress in the virulence-related factors of SS2,e. g. proteins,enzymes,the virulence factor gene expression two-component system and type IV secretion system which interaction to host immune system were summarized. There were valuable references for the treatment of SS2 and vaccine development.

关 键 词：猪链球菌2型 毒力因子 致病机制 

分 类 号：S852.61[农业科学—基础兽医学]