思连康联合锌制剂对小儿腹泻的疗效及对患儿血清指标的影响  

Effect of Siliankang Combined with Zinc Preparations of Infantile Diarrhea and the Influence on Serum Index in Pediatric Patients

作　　者：王吉 左欣鹭 焦健[1] 张爱东[1] 王妍[1] Wang Ji, Zuo Xinlu ,Jiao Jian ,Zhang Aidong ,Wang Yan(Chengde Nursing Vocational College, Chengde, 06700)

机构地区：[1]承德护理职业学院

出　　处：《基因组学与应用生物学》2018年第3期1030-1035,共6页Genomics and Applied Biology

基　　金：承德护理职业学院资助

摘　　要：探讨思连康联合锌制剂治疗小儿迁延性腹泻的临床效果及对患儿血清指标的影响。选取我院收治的120例迁延性腹泻患儿（收治时间2014年1月至2015年1月），根据患儿治疗方法分为治疗组和对照组各60例，对照组采用基础治疗＋锌制剂，治疗组加用思连康治疗，连续治疗10d，对比两组的临床效果。结果显示，接受治疗前，治疗组和对照组患儿的血清IL-6、IL-8、hs-CRP、NO、SOD的水平差异无统计学意义（p〉0．05）。接受治疗后，治疗组患儿的血清IL-6、IL-8、hs—CRP、NO的水平均显著的低于对照组佑〈0．05），治疗组患儿的血清SOD的水平均高于对照组（p〈0.05）；治疗组患儿的大便性状恢复正常、大便次数恢复正常、腹痛消失时间、腹胀消失时间均显著优于对照组患儿，差异具有统计学意义（p〈0．05）。接受治疗10d后，治疗组痊愈率70．00％、显效率21．67％、有效率6．67％、无效1．67％，对照组痊愈率50．00％、显效率35．00％、有效率10．00％、无效5．00％，两组比较差异具有统计学意义（p〈0．05）。思连康联合锌制剂治疗小儿迁延性腹泻能显著的减轻患儿炎症反应程度、恢复内环境的稳定、促进临床症状的缓解，提高治疗效果。The objectives of the research was to investigate the clinical effect of Siliankang combined with zinc preparations on treatment of infantile persistent diarrhea and its influence on serum index in children. 120 cases of children with persistent diarrhea treated in our hospital from January 2014 to January 2015 were selected. According to the treatment methods they were divided into treatment group （60 cases） and control group （60 cases）. Then the control group was treated with basic treatment ＋zinc preparations, and the treatment group was additionally treated with Siliankang. After 10 consecutive days, the clinical effect of two groups were compared. The results showed that before treatment, there was no significant difference in the serum IL-6, IL-8, hs-CRP, NO, SOD level between treatment group and control group （p〉0.05）; after treatment, the serum IL-6, IL-8, hs-CRP and NO levels in the treatment group were significantly lower than the control group （p〈0.05）, but the serum SOD level in the treatment group was higher than the control group （p〈0.05）. Stool characteristics and stool frequency returned to normal, disappearing time of abdominal pain and abdominal distention in treatment group were significantly better than the control group, the difference was statistically significant （p 〈0.05）. After 10 days of treatment, the cure rate of treatment group was 70%, markedly effective rate was 21.67%, effective rate was 6.67%, and the invalid ratio was 1.67%, but the cure rate of the control group was 50%, markedly effective rate was 35%, effective rate was 10%, and invalid ratio was 5%. There was significant difference between two groups （p〈0.05）. Siliankang combined with zinc preparations for treatment of infantile persistent diarrhea in children could significantly reduce the degree of inflammatory reaction and restore the stability of internal environment, promote the clinical symptoms, and improve the therapeutic effect.

关 键 词：多层螺旋CT 缺血 结肠疾病 诊断价值 

分 类 号：R725.7[医药卫生—儿科]