黑腹果蝇伤害性感受研究进展  

Research Progress of Nociception in Drosophila melanogaster

作　　者：郭霞 陈天丽 杨晶晶 覃宏涛 Guo Xia, Chen Tianli ,Yang Jingjing ,Qin Hongtao(College of Biology, Hunan University, Changsha, 41000)

机构地区：[1]湖南大学生物学院

出　　处：《基因组学与应用生物学》2018年第3期1177-1182,共6页Genomics and Applied Biology

基　　金：国家自然科学基金(31371069)资助

摘　　要：伤害性感受（nooception）能够引起机体对伤害性刺激的保护性反应，避免进一步伤害的发生。与这种重要的保护作用相一致的是伤害性感受在进化上高度保守，是包括脊椎、无脊椎动物在内的很多动物的本能反应。黑腹果蝇作为经典的遗传模式生物，已经被成功地应用于伤害性感受的研究当中。果蝇的研究发现了大量的伤害性感受相关基因，对这些基因的深入研究揭示了一些相关分子和神经机制。本研究从热刺激、机械刺激、化学刺激以及电刺激四个方面对果蝇伤害性感受模型的研究进展作一个概述。Nociception can induce organismal protective response to avoid further damage by the nociceptive stimuli. Consistent with its important protective function, nociception was highly conserved during evolution, which was the instinctual response possessed by many vertebrates, invertebrates. Drosophila melanogaster, a classic genetic model organism, has been successfully used in the nociception related researches. The fly studies had identified a large amount of nociception related genes, and further investigations on the function of these nociceptive genes had revealed some molecular and neural mechanisms. In this study, we reviewed recent progress in nociception study on Drosophila melanogaster from the four aspects of thermal stimulation, mechanical stimulation, chemical stimulation and electrical stimulation.

关 键 词：黑腹果蝇 伤害性感受 疼痛 中央复合体 蘑菇体 

分 类 号：Q43[生物学—生理学]