Global Dynamics for an HIV Infection Model with Crowley-Martin Functional Response and Two Distributed Delays  

作　　者：LIU Yongqi WU Chunsong 

机构地区：[1]College of Applied Mathematics, Beijing Normal University, Zhuhai 519087, China [2]College of Mathematics and Information Science, Henan Normal University, Xinxiang 453007, China.

出　　处：《Journal of Systems Science & Complexity》2018年第2期385-395,共11页系统科学与复杂性学报（英文版）

基　　金：supported partially by Scientific Research Staring Foundation,Henan Normal University(qd13045)

摘　　要：In this paper, an HIV dynamics model with two distributed intracellular delays incorporating Crowley-Martin functional response infection rate is investigated. The authors take into account multiple stage disease transmission and the latently infected cells（not yet producing virus） in our system. The authors consider nonnegativity, boundedness of solutions, and global asymptotic stability of the system. By constructing suitable Lyapunov functionals and using the Lyapunov-La Salle invariance principle, the authors prove the global stability of the infected（endemic） equilibrium and the diseasefree equilibrium for time delays. The authors have proven that if the basic reproduction number R_0 is less than unity, then the disease-free equilibrium is globally asymptotically stable, and if R_0 is greater than unity, then the infected equilibrium is globally asymptotically stable. The results obtained show that the global dynamic behaviors of the model are completely determined by the basic reproduction number R_0 and that the time delay does not affect the global asymptotic properties of the model.

关 键 词：Crowley-Martin functional response distributed delays global stability analysis HIV model. 

分 类 号：O175[理学—数学]