替加环素治疗耐碳青霉烯类鲍曼不动杆菌肺炎的疗效观察  

Observation on Efficacy of Tigecycline in Treatment of Carbapenem Resistant Acinetobacter Baumanii Pneumonia

作　　者：杨涛[1] 海峰[1] 杨露[1] YANG Tao, HAI Feng, YANG Lu(Dept. of ICU, the Third People＇s Hospital of Dalian, Liaoning Dalian 116033, Chin)

机构地区：[1]大连市第三人民医院重症医学科,辽宁大连116033

出　　处：《中国医院用药评价与分析》2018年第3期371-373,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨替加环素治疗耐碳青霉烯类鲍曼不动杆菌肺炎的疗效。方法:回顾性选取2013年1月—2016年2月大连市第三人民医院院内感染引起的耐碳青霉烯类鲍曼不动杆菌肺炎患者77例,根据治疗方案分为A组42例和B组35例。A组患者采用替加环素治疗,B组患者采用头孢哌酮舒巴坦钠联合米诺环素治疗。观察两组患者的临床疗效和死亡情况。结果:A、B组患者的总有效率分别为78.57%(33/42)、77.14%(27/35),差异无统计学意义(P>0.05);A、B组患者的病死率分别为21.43%(9/42)、22.86%(8/35),差异无统计学意义(P>0.05)。结论:对于耐碳青霉烯类鲍曼不动杆菌肺炎患者,单独采用替加环素与采用头孢哌酮舒巴坦钠联合米诺环素的临床疗效相近。OBJECTIVE： To probe into the efficacy of tigecycline in treatment of carbapenem resistant acinetobacter baumanii pneumonia. METHODS： 77 patients with carbapenem resistant acinetobacter baumanii pneumonia admitted into the Third People＇s Hospital of Dalian from Jan. 2013 to Feb. 2016 were retrospectively extracted to divided into group A（ 42 cases） and group B（ 35 cases） via different treatment regimen. Patients in group A was given tigecycline,while patients in group B received cefoperazone sodium and sulbactam sodium combined with minocyline. The clinical efficacy and death rate of two groups were observed. RESULTS： The total effective rate of group A and B were respectively 78. 57%（ 33/42） and 77. 14%（ 27/35）,without any statistically significant difference between two groups（ P 0. 05）. The death rate of group A and B were respectively 21. 43%（ 9/42） and22. 86%（ 8/35）,without any statistically significant difference between two groups（ P 0. 05）. CONCLUSIONS：Tigecycline for treatment of carbapenem resistant acinetobacter baumanii pneumonia alone has the similar clinical efficacy with cefoperazone sodium and sulbactam sodium combined with minocycline in internal medical ICU.

关 键 词：替加环素 耐碳青霉烯类鲍曼不动杆菌 肺炎 头孢哌酮舒巴坦钠 米诺环素 

分 类 号：R978.1[医药卫生—药品]