亚胺培南西司他丁钠治疗急诊重症感染的疗效观察  

Observation on Efficacy of Imipenem and Cilastatin Sodium in Treatment of Emergency Severe Infection

作　　者：赵健 侯立成[1] ZHAO Jian, HOU Licheng(Dept. of ICU, Huludao Central Hospital, Liaoning Huludao 125000, Chin)

机构地区：[1]葫芦岛市中心医院重症医学科,辽宁葫芦岛125000

出　　处：《中国医院用药评价与分析》2018年第3期376-377,380,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨亚胺培南西司他丁钠治疗急诊重症感染的临床疗效。方法:选取2015年7月—2016年7月葫芦岛市中心医院收治的急诊重症感染患者114例,以随机数字表法分为观察组和对照组,每组57例。对照组患者给予头孢哌酮钠治疗,观察组患者给予亚胺培南西司他丁钠治疗。观察两组患者的临床疗效、细菌清除情况和不良反应发生情况。结果:观察组患者的总有效率为91.23%(52/57),明显高于对照组的77.19%(44/57),差异有统计学意义(P<0.05);观察组患者细菌总清除率为80.52%(62/77),明显高于对照组的50.67%(38/75),差异有统计学意义(P<0.05);观察组、对照组患者不良反应发生率分别为8.77%(5/57)、12.28%(7/57),差异无统计学意义(P>0.05)。结论:亚胺培南西司他丁钠治疗急诊重症感染的疗效显著,可有效清除病原菌。OBJECTIVE： To probe into the clinical efficacy of imipenem and cilastatin sodium in treatment of emergency severe infection. METHODS： 114 patients with emergency severe infection admitted into Huludao Central Hospital from Jul. 2015 to Jul. 2016 were selected and divided into observation group and control group via random number table,with 57 cases in each. The control group was treated with cefoperazone,while the observation group was given imipenem and cilastatin sodium. The clinical efficacy,bacteria elimination and incidences of adverse drug reactions of two groups were observed. RESULTS： The total effective rate of observation group was 91. 23%（ 52/57）,which was significantly higher than that of the control group（ 77. 19%,44/57）, with statistically significant differences（ P 0. 05）; the total elimination rate of bacteria of observation group was 80. 52%（ 62/77）,which was significantly higher than that of the control group（ 50. 67%,38/75）,with statistically significant differences（ P 0. 05）; the incidences of adverse drug reactions of observation group and control group were respectively 8. 77%（ 5/57） and 12. 28%（ 7/57）,the difference had no statistical significance（ P 0. 05）. CONCLUSIONS： The efficacy of imipenem and cilastatin sodium in treatment of emergency severe infection is remarkable,which can effectively eliminate the pathogenic bacteria.

关 键 词：亚胺培南西司他丁钠 头孢菌素 重症感染 

分 类 号：R978.1[医药卫生—药品]