芪明颗粒对早期糖尿病肾病患者血清Cys-C和β2-MG水平的影响  

Effects of Qiming Granule on Serum Levels of Cys-C and β2-MG in Patients with Early DN

作　　者：王军媛[1] 赵建红[1] 刘颖[1] 张军[1] 李振[1] 臧乐红 王玉红 

机构地区：[1]唐山市中医医院内分泌科,河北唐山063000 [2]唐山市二十二冶医院内二科,河北唐山063000

出　　处：《中医药学报》2018年第2期98-101,共4页Acta Chinese Medicine and Pharmacology

基　　金：2014年度河北省中医药管理局科学技术课题(2014101)

摘　　要：目的:通过观察芪明颗粒对早期糖尿病肾病患者血清胱抑素C与β2微球蛋白的影响,探索其治疗早期糖尿病肾病作用机制。方法:选入符合纳入标准的早期糖尿病肾病患者110例,采用简单随机数字表分为治疗组55例和对照组55例,2组均接受常规的治疗及护理,治疗组给芪明颗粒1袋口服3/日治疗,对照组给予缬沙坦胶囊80 mg口服1/日,治疗16周后观察两组患者血清Cys-C及β2-MG水平的变化,观察两组患者中医症候,统计其临床疗效。结果:治疗组与对照组临床疗效总有效率分别为92.73%、76.36%,比较有显著性差异(P<0.05)。治疗前后两组患者在血清Cys-C及β2-MG方面均有所改善,但是对照组在血清Cys-C及β2-MG方面改善无统计学意义(P>0.05),治疗后治疗组在血清Cys-C及β2-MG方面与对照组比较有显著性差异(P<0.05)。结论:芪明颗粒在改善早期糖尿病肾病中医症候优于对照组,同时也能明显改善血清Cys-C及β2-MG水平,能够延缓糖尿病肾病的发展。芪明颗粒治疗早期糖尿病肾病炎安全有效,为临床广泛应用芪明颗粒提供实验基础。Objective: To observe the effect of Qiming granule on serum Cystatin C( Cys-C) and beta 2-microglobulin( β2-MG) in patients with early diabetic nephropathy( DN),and to explore its action mechanism when treating early DN. Methods: 110 patients with early DN were randomly divided into the treatment group( n = 55) and the control group( n = 55). The both groups were given routine treatment and care; on which basis,the treatment group was also treated with Qiming Granule( 1 bag/time,3 times/day),whereas the control group was given Valsartan Capsule( 80 mg/time,1 time/day). Serum levels of Cys-C and β2-MG,TCM symptoms were observed in the two groups to assess the clinical efficacy. Results: The total clinical efficacy was respectively 92. 73% and 76. 36% in the treatment group and the control group,of which there was a significant difference( P < 0. 05). Serum levels of Cys-C and β2-MG were both improved after the treatment in the two groups,of which there was a statistical significance between the groups( P < 0. 05);however,there was no significant difference between prior treatment and post treatment in the control group( P > 0. 05).Conclusion: Qiming Granule was superior to Valsartan Capsule in improving TCM symptoms of early DN,it can significantly increase the serum levels of Cys-C and β2-MG,it can delay the development of DN. Qiming Granule is safe and effective in the treatment of early DN,which provides reference for the clinical application of Qiming Granule.

关 键 词：芪明颗粒 糖尿病肾病 血清胱抑素C Β2微球蛋白 

分 类 号：R259[医药卫生—中西医结合]