纳米金/石墨烯复合膜修饰电极检测异烟肼  

Preparation of AuNPs/GR/GCE composite film modified electrode for electrochemical detection of isoniazid

作　　者：刘冉彤 于浩[2] 宋诗稳[1] 胡凯 张腾 余紫婷 何国苗 LIU Ran-tong1, YU Hao2 , SONG Shi-wen1, HU Kai1 , ZHANG Teng1 , YU Zi-ting1 and HE Guo- miao1(1. College of Petroleum and Environment Engineering, Yan＇an University, Yan＇an 716000; 2. College of Chemistry and Chemical Engineering, Yah＇an University, Yan＇an 71600)

机构地区：[1]延安大学石油工程与环境工程学院,延安716000 [2]延安大学化工学院,延安716000

出　　处：《分析试验室》2018年第4期466-470,共5页Chinese Journal of Analysis Laboratory

基　　金：延安大学校级科研项目(YDQ2017-19);延安大学大学生创新创业训练项目(D2016040)资助;陕西省教育厅专项项目(16JK1865)

摘　　要：先采用滴涂法制备了石墨烯修饰电极(GR/GCE),然后采用电化学方法将纳米金沉积于石墨烯表面制备了纳米金/石墨烯复合材料修饰电极(Au NPs/GR/GCE)。研究了异烟肼(isoniazid,INZ)在该Au NPs/GR/GCE上的电化学行为。结果表明,异烟肼在该修饰电极上有良好的电化学响应。在优化条件下,线性扫描伏安法测定异烟肼的线性范围为1.0×10-7~1.0×10-4mol/L,检出限为5.0×10-8mol/L(S/N=3)。用该法测定了异烟肼注射液中异烟肼的含量,结果令人满意。A nano gold/graphene composite film modified electrode（ Au NPs/GR/GCE） was fabricated by using electrochemical methods. The electrochemical behavior of isoniazid（ INZ） at the modified electrode was investigated. The results showed that the resulting modified electrode had high electrocatalytic activity for the oxidation of INZ. Under the optimal conditions,the linear range for determination of INZ was 1. 0 × 10-7~ 1. 0 × 10-4 mol/L with the detection limit of 5. 0 ×10-8 mol/L（ S/N = 3）. Finally,this method was successfully employed to determine isoniazid in injection.

关 键 词：纳米金 石墨烯 化学修饰电极 异烟肼 

分 类 号：R917[医药卫生—药物分析学] O657.1[医药卫生—药学]