回药扎里奴思方对不同证型急性脑梗死患者神经功能恢复的影响  

Effects of Zhali Nusi Fang on recovery of neurological function in patients with acute cerebral infarction of different syndromes

作　　者：顾玉宝[1] 刘敬霞 刘超[1] 王枫[1] 甘佳乐 李娟[1] GU Yu-Bao, LIU Jing-Xia, LIU Chao, et al(Ningxia Medical University, Yinchuan 750004, Ningxia, China)

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]宁夏医科大学回医药现代化省部共建教育部重点实验室

出　　处：《中国老年学杂志》2018年第7期1537-1540,共4页Chinese Journal of Gerontology

基　　金：国家十二五科技支撑项目(SQ2013SF12E02181)

摘　　要：目的观察扎里奴思方(扎方)对不同证型急性脑梗死(ACI)患者神经功能恢复的影响,明确方治疗ACI的适宜证型。方法 150例ACI患者辨证分为痰瘀阻络证、痰热腑实证、气虚血瘀证、风火上扰证和阴虚风动证组。各组治疗期间均给予同等基础治疗及口服扎方,1剂/d,2次/d,14 d为1个疗程。比较治疗前后各组临床疗效、神经功能缺损(NIHSS)评分及日常生活活动能力(ADL)积分的变化。结果各组治疗后疗效显著优于治疗前(P<0.05),且痰瘀阻络证组疗效最优;与治疗前比较各组NIHSS评分显著降低,ADL积分显著升高(P<0.05,P<0.01),其中痰瘀阻络证组治疗后6个月时改善程度较其他组尤为明显(P<0.05)。结论 ACI患者予以扎方治疗有助于促进缺损神经功能的恢复,改善脑梗死(CI)后活动不利及提高ADL,其中对痰瘀阻络证患者的临床疗效尤为明显,其作用与扎方化痰逐瘀的功效具有一致性。Objective To observe the effects of Zhali Nusi Fang（ZLNSF） on recovery of neurological function in patients with acute cerebral infarction of different syndromes, and to clarify the appropriate syndrome for ZLNSF. Methods 150 patients with acute cerebral in- farction were divided into five groups according to syndrome differentiation, including syndrome of phlegm and blood stasis, syndrome of phlegm heat and bowel excess, syndrome of qi deficiency and blood stasis, syndrome of wind and fire on the disturbance card, syndrome of Yin deficiency and wind stirring. The clinical efficacy, neurological deficit （NIHSS） score and the daily living activity（ADL） score of each group were compared before and after treated. Results The NIHSS score of patients was significantly lower, ADL score was significantly higher （ P〈0.05 ）, especially 7 and 14 days after treated. The patients with phlegm and blood stasis syndrome were improved more than others. Conclusions ZLNSF could promote the recovery of defects nerve function,improve the activities of the adverse and daily living capacity decline after cerebral infarction,which is particularly evident in patients of phlegm and blood stasis syndrome,this role is consistent with the effects of phlegm and blood stasis of ZLNSF.

关 键 词：扎里奴思方 急性脑梗死 中医证型 神经功能 

分 类 号：R285.5[医药卫生—中药学]