DSC法鉴别高风险塑料输液产品  

Identification of Plastic Infusion Products of High Risk by DSC

作　　者：王丹丹 陈超[1] 陈瑜 俞辉 WANG Dandan1,2, CHEN Chao1, CHEN Yu1, YU Hu1(1.Zhejiang Institute for Food and Drug Control, Key Labdratory of Drug Contacting Materials Quality Control of Zhejiang Province, Hangzhou 310052, China; 2.Zhejiang University of Technology, Hangzhou 310004, Chin)

机构地区：[1]浙江省食品药品检验研究院,浙江省药品接触材料质量控制研究重点实验室,杭州310052 [2]浙江工业大学,杭州310004

出　　处：《中国现代应用药学》2018年第2期174-176,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的建立高风险塑料输液产品的差示扫描量热分析鉴别方法。方法初始温度40℃,以20℃·min^(-1)加热到200℃,再以20℃·min^(-1)降温到40℃,然后以10℃·min^(-1)加热到200℃,记录DSC图谱。结果聚丙烯输液瓶、塑料输液容器用聚丙烯组合盖(拉环式,内盖)、三层共挤输液用膜(袋)和五层共挤输液用膜(袋)均显示其特征DSC图谱。结论该方法准确、灵敏、简便,适用于对高风险塑料输液产品的鉴别。OBJECTIVE To develop a method for identification of plastic infusion products of high risk by differential scanning calorimetry（DSC）.METHODS The initial temperature was 40 ℃,then heated to 200 by 20℃ ℃·min^（-1）,cooled to 40 ℃by 20 ℃·min^（-1）,then heated to 200 ℃ by 10 ℃·min^（-1）,recorded the DSC spectrum.RESULTS PP infusion bottles,combinational closures of PP for plastic infusion containers（with ring-pull）（inner closure）,3-layer co-extrusion film（bag） for infusion,5-layer co-extrusion film（bag） for infusion showed specific DSC spectrum,respectively.CONCLUSION This method is accurate,sensitive,simple,it can be used for identification of plastic infusion products of high risk.

关 键 词：差示扫描量热法 塑料输液产品 聚丙烯输液瓶 塑料输液容器用聚丙烯组合盖(拉环式) 三层共挤输液用膜(袋) 五层共挤输液用膜(袋) 

分 类 号：R917.1[医药卫生—药物分析学]