不同剂量硫磺熏蒸对党参化学成分的影响  

Effect on Chemical Constituents of Codonopsis Radix Fumigated in Different Sulfur Dosages

作　　者：杨军宣[1] 郭振宇[1] 张毅 吕志勇[1] 吕姗珊 周年华 YANG Junxuan1, GUO Zhenyu1, ZHANG Yi2, LYU Zhiyong1, LYU Shanshan3, ZHOU Nianhua3(1.TCMSchool of Chongqing Medical University, Chongqing 400016, China;2.Chongqing Institute for Food and Drug Control, Chongqing 401121, China;3. Chongqing Healn Pharmaceutical Co., Ltd., Chongqing 401121, Chin)

机构地区：[1]重庆医科大学中医药学院,重庆400016 [2]重庆市食品药品检验检测研究院,重庆401121 [3]重庆希尔安药业有限公司,重庆401121

出　　处：《中国现代应用药学》2018年第2期235-238,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：重庆市卫生和计划生育委员会中医药科技项目(ZY201702132)

摘　　要：目的研究不同剂量硫磺熏蒸对党参化学成分的影响及硫熏党参贮藏不同时间化学成分的变化,为党参饮片的科学炮制及质量评价提供参考。方法不同剂量硫磺熏蒸党参并贮藏12个月,采用UV及HPLC测定党参多糖、5-羟甲基糠醛、党参炔苷等化学成分的变化。结果硫磺熏蒸对党参多糖的影响较小,最高剂量(2.0%)硫熏,放置12个月,多糖含量降低5.83%;对5-羟甲基糠醛、党参炔苷的影响大,最高剂量(2.0%)硫熏,放置12个月,5-羟甲基糠醛含量增加83.27%,党参炔苷含量降低54.09%。结论硫熏对党参化学成分有显著影响。应严格控制药材加工处理及炮制过程中硫磺的使用,确保中药材及饮片的质量。OBJECTIVE To study the effect on chemical constituents of Codonopsis Radix fumigated in different sulfur dosages and stored at different time,so as to provide reference for the processing and quality evaluation of Codonopsis Radix pieces.METHODS UV and HPLC methods were used to determine polysaccharide,5-hydroxymethylfurfural and lobetyolin of Codonopsis Radix after being fumigated in different sulfur dosages and storing for 12 months.RESULTS Sulfur fumigation had little influence on the polysaccharides,and had great influence on the 5-hydroxymethylfurfural and lobetyolin.After 12 months,the content of polysaccharide decreased by 5.83%,the content of 5-hydroxymethylfurfural increased by 83.27% and the content of lobetyolin decreased by 54.09%.CONCLUSION Sulfur fumigation has a significant effect on the chemical constituents of Codonopsis Radix.It should be strictly control the use of sulfur in the processing of Chinese medicinal herbs,so as to ensure the quality of Chinese medicinal herbs.

关 键 词：党参 硫磺熏蒸 多糖 5-羟甲基糠醛 党参炔苷 

分 类 号：R284.2[医药卫生—中药学]