Interaction of antipsychotic drug with novel surfactants: Micellization and binding studies  

作　　者：Naved Azum Malik Abdul Rub Abdullah M.Asiri 

机构地区：[1]Center of Excellence for Advanced Materials Research, King Abdulaziz University [2]Chemistry Department, Faculty of Science, King Abdulaziz University

出　　处：《Chinese Journal of Chemical Engineering》2018年第3期566-573,共8页中国化学工程学报（英文版）

基　　金：Chemistry Department and Centre of Excellence for Advanced Materials Research, King Abdulaziz University

摘　　要：The interaction of cationic gemini surfactants(alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug(chlorpromazine hydrochloride(CPZ)) has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh's theory. The results indicate synergism in the binary mixtures.The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV–visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.The interaction of cationic gemini surfactants （alkanediyl-α,ω-bis（alkyl dimethylammonium bromide）） with an antipsychotic drug （chlorpromazine hydrochloride （CPZ）） has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh＇s theory. The results indicate synergism in the binary mixtures. The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV-visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.

关 键 词：Gemini surfactants Antipsychotic drug Chlorpromazine hydrochloride Mixed micellization 

分 类 号：O647.2[理学—物理化学] TQ460.1[理学—化学]