维生素D与肾病综合征的相关性  

Correlation between vitamin D and nephrotic syndrome

作　　者：冯爱静 吴红赤[1] FENG Aijing, WU Hongchi(Department of Nephrology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Chin)

机构地区：[1]哈尔滨医科大学附属第一医院肾内科,哈尔滨150001

出　　处：《临床与病理杂志》2018年第2期429-432,共4页Journal of Clinical and Pathological Research

基　　金：黑龙江省教育厅科学技术研究项目(12541264)~~

摘　　要：维生素D是一种人体必需的脂溶性维生素,也是一种类固醇激素,通过其活性形式作用于维生素D受体发挥作用。除经典的调节钙、磷代谢的作用外,近期研究发现维生素D还有调节免疫功能、抑制炎症反应、抑制细胞的增殖、分化等非经典作用。肾病综合征(nephrotic syndrome,NS)是一种由免疫紊乱引起的常见的肾脏疾病,其病理生理的改变及糖皮质激素的应用可影响维生素D的代谢。因此维生素D水平与NS具有密切相关性。Vitamin D is a kind of essential fat-soluble vitamins in human body, as well as a kind of steroid hormone. Vitamin D plays a role through its active form acting on a vitamin D receptor. In addition to the role in the regulation of calcium and phosphorus metabolism, recent studies have found that vitamin D also regulate immune function, inhibit inflammatory response, inhibit cell proliferation, differentiation and other non-classical role. Nephrotic syndrome（NS） is a common kidney disease caused by immune disorders. The changes of its pathophysiology and the use of glucocorticoids can affect the metabolism of vitamin D. Vitamin D levels are closely related to NS.

关 键 词：维生素D 维生素D受体 肾病综合征 

分 类 号：R692[医药卫生—泌尿科学]