特发性脊柱侧弯患者血清维生素D水平及其临床意义  

Serum levels of vitamin D in patients with idiopathic scoliosis and its clinical significance

作　　者：温超轮[1] 扶晓明[1] 谭雄进[1] 朱志勇[1] 阳海波 蒋飞龙 曾昭池[1] WEN Chao-lun,FU Xiao-ming,TAN Xiong-jin,ZHU Zhi-yong, YANG Hai-bo,JIANG Fei-long,ZENG Zhao-chi(Department of Orthopedics,No. 196 Central Hospital of the People＇s Liberation Army , Hengyang 421002 ,Chin)

机构地区：[1]中国人民解放军第一六九中心医院骨科,湖南衡阳421002

出　　处：《现代医学》2018年第1期57-59,共3页Modern Medical Journal

摘　　要：目的:探究特发性脊柱侧弯患者血清维生素D水平及其临床意义。方法:选取我院2014年1月至2017年1月诊断为特发性脊柱侧弯患者200例为观察组,并选取健康体检中心年龄、性别与之相匹配的健康受试者200例为对照组,比较两组受试者血清维生素D水平,并分析观察组患者血清维生素D水平与碱性磷酸酶(ALP)、血钙、血磷、Cobb's角及年龄的关系。结果:(1)观察组维生素D水平显著低于对照组,差异有统计学意义(P<0.05)。(2)观察组Cobb's角>45°的患者维生素D水平显著低于Cobb's角≤45°患者,差异有统计学意义(P<0.05)。(3)观察组维生素D水平与血钙呈正相关(r=0.175,P=0.01),与Cobb's角呈负相关(r=-0.425,P=0.02),与年龄、ALP、血磷无显著相关性。结论:维生素D缺乏可能与特发性脊柱侧弯的发生发展相关,检测维生素D有助于特发性脊柱侧弯严重程度的判断。Objective： To investigate the level of serum vitamin D in patients with idiopathic scoliosis and its clinical significance. Methods： Two hundreds cases of idiopathic scoliosis diagnosed in our hospital from January2014 to January 2017 were selected as the observation group and 200 cases healthy subjects whose age and gender matched were selected as the control group. Serum vitamin D level were compared between the two groups. The relationship between serum vitamin D level and alkaline phosphatase（ ALP）,serum calcium,serum phosphorus,Cobb＇s angle and age in observation group were analyzed. Results：（ 1） The level of vitamin D in observation group was significantly lower than that in the control group,the difference was statistically significant（ P〈0. 05）.（ 2） In the observation group the vitamin D of the patients whose Cobb＇ s angle 45° were significantly lower than those whose Cobb＇s angle≤45°,the difference was statistically significant（ P〈0. 05）.（ 3） The level of vitamin D was positively correlated with blood calcium（ r = 0. 175,P = 0. 01）,and negative correlated with Cobb＇ s angle（ r =-0. 425,P = 0. 02）. And there were no relationship between the level of vitamin D and age,ALP and serum phosphorus. Conclusion： Vitamin D deficiency may be associated with the occurrence and development of idiopathic scoliosis and detection of vitamins D could help to determine the severity of idiopathic scoliosis.

关 键 词：特发性脊柱侧弯 维生素D Cobb's角 

分 类 号：R259[医药卫生—中西医结合]