基于广州生物库的广州市中老年人饮酒行为改变及其影响因素的前瞻性队列研究  

A prospective cohort study of drinking behavior changes and influencing factors in middle age and elderly people with the Guangzhou Biobank Cohort

作　　者：沈振敏 江朝强 张维森 郑家强[2] 徐琳[3] 靳雅丽 胡强 朱峰 林大庆[4] SHEN Zhen-min;JIANG Chao-qiang;ZHANG Wei-sen;CHENG Kar-keung;XU Lin;JIN Ya-li;HU Qiang;ZHU Feng;LAM Tai-hing(Molecular Epidemiology Research Center, the l 2th Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province 510620, Chin)

机构地区：[1]广州医科大学附属市十二人民医院分子流行病学研究室,广东省广州510620 [2]英国伯明翰大学公共卫生与流行病学系 [3]中山大学公共卫生学院流行病教研室 [4]香港大学公共卫生学院社会医学系

出　　处：《中国慢性病预防与控制》2018年第3期161-166,共6页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：国家重点研发计划项目(2017YFC0907100);广东省自然科学基金资助项目(2015A030313891)

摘　　要：目的探讨广州市中老年人饮酒行为改变及其相关影响因素,为推动中老年人群饮酒控制工作提供科学参考。方法选取广州生物库队列研究(GBCS)基线(2003年9月至2008年1月)和第1次随访(2008年3月至2012年12月)调查的17 672名50岁以上广州中老年人作为研究对象,问卷调查一般人口学信息、社会经济地位(文化程度、职业和收入等)、婚姻状态(已婚、未婚、丧偶、分居或离婚等)、生活方式(吸烟及体力运动等)、自报个人疾病史以及自评健康状况,调查研究对象饮酒情况并随访其饮酒行为改变情况。采用SPSS 19.0软件进行t检验和χ~2检验,用多因素logistic逐步回归模型分析基线人群一般人口学特征、酒精相关疾病和自评健康状况等对饮酒行为改变的影响。结果本队列中共纳入17 672名研究对象,男性占27.0%,平均随访(4.1±1.1)年。基线不饮酒或偶饮酒者中有221名(6.0%)男性和328名(2.7%)女性随访期间转为经常饮酒,其中男性转为适量饮酒者占转为经常饮酒者的99.5%,女性占97.9%。基线适量饮酒者中有261名(62.0%)男性和251名(83.9%)女性随访期间减量为不饮酒或偶饮酒;基线过量饮酒者中有249名(58.9%)男性和57名(79.2%)女性随访期间减量为适量饮酒、不饮酒或偶饮酒。多因素logistic逐步回归分析结果显示,女性年龄(OR=1.02,95%CI:1.01~1.04)、居住郊区(OR=1.32,95%CI:1.04~1.68)、患心血管疾病(OR=1.57,95%CI:1.14~2.15)、自评健康状况好(OR=1.51,95%CI:1.17~1.93)与基线不饮或偶饮酒随访期间转为适量饮呈正相关,女性患血脂异常(OR=0.77,95%CI:0.61~0.96)与基线不饮或偶饮酒随访期间转为适量饮呈负相关,均有统计学意义(P<0.05,P<0.01);女性患心血管疾病(OR=0.47,95%CI:0.23~0.96)和男性患糖尿病(OR=2.62,95%CI:1.29~5.30)分别与基线适量饮酒随访期间减量为不饮酒或偶饮酒呈负相关和正相关,均有统计学意义(P<0.05,P<0.01);女性单身(OR=0.15,95%CIObjective To explore the drinking behavior changes and influencing factors in middle age and elderly people of Guangzhou, and to provide the scientific evidence for alcohol control in middle age and older people. Methods From the data for both baseline（from September 2003 to January 2008） and follow-up（from March 2008 to December 2012）, 17 672 cases（≥50 years old） of the Guangzhou Biobank Cohort Study（GBCS） were selected as the subjects. The investigation was performed with the questionnaire which included the general demographic information, socioeconomic status（educational level, occupation and income）, marriage（married and unmarried, widowed, separated or divorced, etc）, life-style（smoking and physical activity, etc）,self-reported individual disease history and self-assessed health, drinking behavior at baseline and changes in drinking behavior during the follow-up. The t test and χ~2 test were used to analyze the data, and the used software was SPSS 19.0, the multivariate logistic stepwise regression was used to analyze the association of baseline demographic characteristics, alcohol related diseases,self-assessed health at baseline with the changes in drinking behavior. Results The subjects were 17 672 cases（males： 27.0%）.The average followed-up duration was（4.1±1.1） years. Of the occasional or non-drinkers, 221 males（6.0%） and 328 females（2.7%） changed to frequent drinkers, 99.5% males and 97.9% females of frequent drinkers were moderate drinkers. Of the moderate drinkers, 261（62.0%） males and 251（83.9%） females changed to occasional or non-drinkers. Of the excessive drinkers,249（58.9%） males and 57（79.2%） females changed to moderate, occasional or non-drinkers. The results of multivariate logistic stepwise regression analysis showed that of the occasional or non-drinkers at baseline, female, age（OR=1.02, 95%CI： 1.01-1.04）,suburban residents（OR=1.32, 95%CI：1.04-1.68）, cardiovascular disease（OR=1.57, 95%CI： 1.14-2.15）, good s

关 键 词：中老年人 饮酒行为改变 前瞻性队列研究 广州生物库队列 

分 类 号：R163[医药卫生—公共卫生与预防医学]