Specific White Matter Impairments in Patients with Treatment-Refractory First-Episode Schizophrenia： A 1-Year Follow-up Pilot Study  

作　　者：Min Chen Chuan-Jun ZhUO Li-Ju Qian Bin Wang Jin-Guo Zhai Feng Ji Xiao-Yan Ke 

机构地区：[1]Department of Psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210029, China [2]Department of Psychiatry, Jining Neuro-Psychiatric Hospital, Jining, Shandong 272051, China [3]Department of Psychiatry-Neuroimaging Key Laboratory, Tianjin Mental Health Center, Nankai University Affiliated Tianjin Anding Hospital Tianjin 300222, China [4]Department of Psychiatry, School of Mental Health, Jining Medical University, Jining, Shandong 272067, China

出　　处：《Chinese Medical Journal》2018年第7期879-880,共2页中华医学杂志（英文版）

摘　　要：To the Editor： In the last 10 years, mounting evidence has confirmed that schizophrenia is associated with white matter （WM） impairment; this impairment exists even before the occurrence of an episode of schizophrenic symptoms. Widespread WM fiber tracts were affected in patients, especially in certain key brain regions, such as the arcuate fasciculus, fasciculi longitudinalis superior, and corpus callosum. A previous study reported that although there was no more than 1% WM impairments in schizophrenic patients, it is nonetheless a stable and specific aberrant pathological feature of schizophrenia.To the Editor： In the last 10 years, mounting evidence has confirmed that schizophrenia is associated with white matter （WM） impairment; this impairment exists even before the occurrence of an episode of schizophrenic symptoms. Widespread WM fiber tracts were affected in patients, especially in certain key brain regions, such as the arcuate fasciculus, fasciculi longitudinalis superior, and corpus callosum. A previous study reported that although there was no more than 1% WM impairments in schizophrenic patients, it is nonetheless a stable and specific aberrant pathological feature of schizophrenia.

分 类 号：TP311.13[自动化与计算机技术—计算机软件与理论] R749.3[自动化与计算机技术—计算机科学与技术]