法舒地尔联合舒利迭对COPD合并PAH患者肺功能及血清BNP、CRP、IL-8、TNF-α水平的影响  

Effect of Fasudil Combined with Seretide on Lung Function and Serum Levels of BNP, CRP, IL-8 and TNF-α of Patients with COPD and PAH

作　　者：卜容蓉 阵娜 李丹 朱凤[1] 杨才勇[1] BU Rong-rong1,ZHEN Na2,LI Dan1,ZHU Feng1,YANG Cai-yong1(1 Ankang Central Hospital, Ankang, Shaanxi, 725000, China; 2 The First Affiliated Hospital of Xi＇an Jiao Tong University, Xi＇an, Shaanxi, 710061, Chin)

机构地区：[1]安康市中心医院,陕西安康725000 [2]西安交通大学第一附属医院,陕西西安710061

出　　处：《现代生物医学进展》2018年第4期737-740,661,共5页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(2002C255)

摘　　要：目的:探讨法舒地尔联合舒利迭对慢性阻塞性肺疾病(COPD)合并肺动脉高压(PAH)患者的肺功能及血清脑钠肽(BNP)、C反应蛋白(CRP)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平的影响。方法:选择我院2015年2月~2017年1月收治的108例COPD合并PAH患者作为研究对象,根据患者入院顺序编号,采取随机数字表分成观察组(n=54)与对照组(n=54)。两组均给予常规治疗,观察组在常规治疗基础上联合给予法舒地尔与舒利迭治疗,对两组患者进行疗效评估,比较两组患者治疗前后的肺功能、血气分析指标以及血清BNP、CRP、IL-8、TNF-α水平的变化。结果:治疗后,两组患者的FEV1%pre、FEV1/FVC、PaO_2均较治疗前显著升高(P<0.05),且观察组FEV1%pre、FEV1/FVC、PaO_2明显高于对照组(P<0.05);两组患者的PaCO_2、SPAP、Tei指数、血清BNP、CRP、IL-8、TNF-α水平均较治疗前显著下降(P<0.05),且观察组PaCO_2、SPAP、Tei指数、血清BNP、CRP、IL-8、TNF-α水平均明显低于对照组(P<0.05)。结论:法舒地尔联合舒利迭治疗COPD合并PAH能有效改善患者的肺功能,减轻炎症反应,降低肺动脉压,疗效确切。Objective： To investigate the effect of Fasudil combined with Seretide on the pulmonary function and serum levels of serum brain natriuretic peptide（BNP）, C reactive protein（CRP）, interleukin-8（IL-8）, and tumor necrosis factor-α（TNF-α） of patients with chronic obstructive pulmonary disease（COPD） complicated with pulmonary arterial hypertension（PAH）. Methods： 108 cases of COPD combined with PAH patients treated in our hospital from February 2015 to January 2017 were selected and numbered according to the admission order and then they were divided into the observation group（n=54） and the control group with the method of random number table（n=54）. Both groups were given conventional treatment, and the observation group was combined with Fasudil and Seretide on the basis of conventional treatment. Then the curative effect of the two groups of patients was evaluated. The lung function, blood gas analysis index, and serum BNP, CRP, IL-8 and TNF-α levels were compared between two groups before and after the treatment. Results：After the treatment, the FEV1% pre, FEV1/FVC and PaO2 of patients in both groups were significantly higher than those before the treatment（P〈0.05）, which were obviously higher in the observation group than those of the control group（P〈0.05）. The PaCO2, SPAP, Tei index serum BNP, CRP, IL-8, TNF-α levels of both groups were significantly higher than those before the treatment（P〈0.05）, which were significantly lower in the observation group than those of the control group（P〈0.05）. Conclusion： Fasudil combined with Seretide can effectively improve the pulmonary function, relieve the inflammation and reduce the pulmonary artery pressure in the treatment of COPD combined with PAH.

关 键 词：法舒地尔 舒利迭 慢性阻塞性肺疾病 肺动脉高压 炎症反应 

分 类 号：R563[医药卫生—呼吸系统]