心肌肥厚信号通路研究进展  

Research Progress of Signaling Pathway in Myocardial Hypertrophy

作　　者：于亚楠[1] 杜玉颖 李旭 李秀姿 孟思妤[1] 姚天明[3] YU Ya-nan1,DU Yu-ying2,LI Xu2,LI Xiu-zi2,MENG Si-yu1,YAO Tian-ming3(1 School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical Universiy, Shenyang, Liaoning, 110016, China; 2 Jinzhou Medical University Jinzhou, Liaoning, 121000, China; 3 Medical deparment, General Hospital of Shenyang Military Region, Shenyang, Liaoning, 110840, China)

机构地区：[1]沈阳药科大学生命科学与生物制药学院,辽宁沈阳110016 [2]锦州医科大学,辽宁锦州121000 [3]沈阳军区总医院医务部,辽宁沈阳110840

出　　处：《现代生物医学进展》2018年第4期779-782,共4页Progress in Modern Biomedicine

基　　金：辽宁省百千万人才"千人层次计划"基金项目(2014921031)

摘　　要：病理性心肌肥厚是心肌细胞受到多种因素刺激后所产生的失代偿性反应,最终可演变为心力衰竭,甚至诱发猝死。鉴于其复杂的病理过程,具体发病机制至今尚未完全阐明,但既有研究已明确有丝分裂原活化蛋白激酶信号通路、Ca^(2+)介导的信号通路、蛋白激酶信号通路、Janus激酶/信号转导子和转录激活子信号通路和MicroRNAs信号通路在调控心肌肥厚的进程中起着至关重要的作用。现就相关信号通路在心肌肥厚发生、进展及预后中所起作用的最新研究进展予以综述。Pathological myocardial hypertrophy is a decompensated response of myocardial cells stimulated by a variety of factors, which can eventually develop into heart failure, and even lead to sudden death. Due to its complex pathological process, the specific pathogenesis has not been fully elucidated. But the existing studies have shown that mitogen-activated protein kinase pathway,Ca^2＋ mediated signaling pathway, protein kinase pathway, Janus kinase/signal transducer and activator of transcription signal pathway and MicroRNAs signal pathway play very important roles in the regulation of myocardial hypertrophy. This paper reviews the recent progress in the study of the role of related signaling pathways of myocardial hypertrophy.

关 键 词：信号通路 信号转导 心肌肥厚 心衰 

分 类 号：R542.2[医药卫生—心血管疾病]