枸杞多糖通过保护海绵体内皮功能改善糖尿病大鼠勃起功能障碍  

Lycium barbarum polysaccharide improves erectile dysfunction in diabetic rats by protecting cavernous endothelial function

作　　者：黄小军 丁协刚[2] 李虎宜 梁志恒 刘卫华 张李晓 Huang Xiaojun1 , Ding Xiegang2 , Li Huyi1 , et al.(1 Department of Urology, Dongfeng Hospital Affiliated to Hubei Medical College, Shiyan 442000, China ; 2 Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China)

机构地区：[1]湖北医药学院附属东风医院泌尿外科,湖北十堰442000 [2]武汉大学中南医院泌尿外科,湖北武汉430071

出　　处：《国际泌尿系统杂志》2018年第2期262-265,共4页International Journal of Urology and Nephrology

基　　金：十堰市科学技术研究与开发项目（14Y57）

摘　　要：目的观察分析枸杞多糖对糖尿病勃起功能障碍大鼠海绵体内皮功能保护的作用。方法使用枸杞多糖对糖尿病勃起功能障碍大鼠进行治疗，并设立糖尿病（DM）阴茎勃起功能障碍（ED）组和正常对照组，检测治疗后阴茎勃起功能，电击刺激海绵体神经，检测海绵体内压力（ICP）和平均动脉压（MAP），使用TUNEL法检测海绵体细胞凋亡情况，对海绵体组织进行石蜡切片和HE染色后检测海绵体内血管数量。结果枸杞多糖治疗组、DMED组治疗前后大鼠勃起率、治疗后ICP、ICP／MAP及海绵体细胞凋亡率与正常对照组大鼠相比较差异均有统计学意义（P〈0．05），枸杞多糖治疗组治疗后大鼠勃起率、ICP、ICP／MAP及海绵体细胞凋亡率与DMED组相比较差异有统计学意义（P〈0．05），DMED组大鼠治疗后海绵体毛细血管数与正常对照组大鼠相比较差异有统计学意义（P〈0．05），枸杞多糖治疗组大鼠治疗后海绵体毛细血管数与DMED组相比较差异有统计学意义（P〈0．05）。结论枸杞多糖对糖尿病大鼠海绵体内皮功能具有明显改善作用，对糖尿病大鼠阴茎勃起功能障碍具有良好的治疗效果。Objective To observe the effect of lycium barbarum polysaccharide（LBP） on the function of cavernous endothelial function in diabetic erectile dysfunction rats. Methods The rats were treated with LBP and devided into DMED and normal control group. The erectile function and electric stimulation of corpus cavernosum were measured, and the intracavernous pressure （ICP） and mean arte- rial pressure （MAP） were measured. TUNEL method was used to detect the apoptosis of corpus caverno- stun. The number of cavernous body was detected by paraffin section and HE staining. Results In the LBP treatment group, the erectile rate, the ICP, ICP / MAP and the cavernous cell apoptosis rate of the DMED group were significantly different from those of the normal control group （ P 〈 0.05 ）, the LBP treatment group （ P 〈 0.05 ）. Compared with DMED group, the number of cavernous capillaries in the DMED group was significantly lower than that in the control group （P 〈 0.05 ）. The number of cavernous capillaries in DMED group was significantly higher than that in the control group （ P 〈 0.05）. Compared with DMED group, the number of cavernous capillaries in rats treated with LBP was significantly differ- ent （ P 〈 0.05 ）. Conclusions LBP on diabetic rats can significantly improve function of cavernous en- dothelial and has a good therapeutic effect for erectile dysfunction in diabetic rats.

关 键 词：勃起功能障碍 枸杞子 多糖类 内皮 大鼠 

分 类 号：R285.5[医药卫生—中药学]