维生素E对骨性关节炎氧自由基水平的影响及意义  

Effect and significance of Vitamin E on oxgen free radicals levels in patients with osteoarthritis

作　　者：程兆明[1] 王苏芹[1] 庄禄昌 刘小林[1] 冯康[1] 寇剑铭[1] ~heng Zhaoming, Wang Suqin, Zhuang Luchang, Liu Xiaolin, Feng Kang, Kou Jianming(Department of Orthopedics, the Second People＇s Hospital of Lianyungang , Lianyungang 222023, Chin)

机构地区：[1]江苏省连云港市第二人民医院骨科,222023

出　　处：《中国实用医刊》2018年第1期17-19,共3页Chinese Journal of Practical Medicine

基　　金：蚌埠医学院科研课题（byky13124）

摘　　要：目的探讨维生素E对骨性关节炎（OA）患者氧自由基水平的影响及意义。方法47例（48膝）OA患者按照随机数字表法分为实验组24例（24膝）与对照组23例（24膝）。实验组给予玻璃酸钠联合维生素E治疗，对照组给予玻璃酸钠治疗，检测两组治疗前后一氧化氮（NO）、丙二醛（MDA）、超氧化物岐化酶（SOD）的水平变化情况，采用西安大略和麦克马斯特大学骨关节炎指数评分及OA严重程度指数（ISOA指数）观察并评价患者关节功能。结果OA患者NO、MDA水平较高，而SOD水平较低。治疗后，实验组NO、MDA含量低于对照组，而SOD的水平高于对照组（P〈0．05）。结论维生素E能有效降低骨关节炎患者血清NO和MDA含量，提高血清SOD活性，清除氧自由基，改善关节功能。Objective To investigate the clinical effect of Vitamin E on patients with osteoarthritis （OA） and its effect on oxygen free radical levels. Methods Forty-seven patients （48 knees） with OA were randomly divided into study group [ 24 cases （24 knees）] and control group [ 23 cases （24 knees） ]. Patients in study group were treated with Vitamin E and sodium hyaluronate injection, and patients in control group were treated with sodium hyaluronate injection. The levels of serum nitric oxide （NO）, malondialdehyde （MDA） and superoxide dismutase （SOD） before and after treatment in the two groups were detected ; and the function of knee joint were obseroed and evaluated with the Western Ontario and McMaster Universities osteoarthritis index （WOMAC） and index of severity of osteoarthritis （ISOA）. Results The levels of NO and MDA in study group were significantly lower than those in control group, but the level of SOD in study group was significantly higher than that in control group （P 〈 0. 05）. Conclusions Vitamin E can effectively reduce the levels of NO and MDA and increase the activity of serum SOD in osteoarthritis patients, scavenge oxygen free radicals and improve joint function.

关 键 词：维生素E 骨性关节炎 氧自由基 超氧化物岐化酶 

分 类 号：R684.3[医药卫生—骨科学]